Dynamin-Related Protein-1 Controls Fusion Pore Dynamics During Platelet Granule Exocytosis

OBJECTIVE—Platelet granule exocytosis serves a central role in hemostasis and thrombosis. Recently, single-cell amperometry has shown that platelet membrane fusion during granule exocytosis results in the formation of a fusion pore that subsequently expands to enable the extrusion of granule content...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2013-03, Vol.33 (3), p.481-488
Hauptverfasser:	Koseoglu, Secil, Dilks, James R, Peters, Christian G, Fitch-Tewfik, Jennifer L, Fadel, Nathalie A, Jasuja, Reema, Italiano, Joseph E, Haynes, Christy L, Flaumenhaft, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterioles - injuries Blood Platelets - drug effects Blood Platelets - metabolism Disease Models, Animal Dynamins - antagonists & inhibitors Dynamins - blood Exocytosis - drug effects Fibrinolytic Agents - pharmacology GTP Phosphohydrolases - antagonists & inhibitors GTP Phosphohydrolases - blood Humans Lasers Membrane Fusion - drug effects Mice Microtubule-Associated Proteins - antagonists & inhibitors Microtubule-Associated Proteins - blood Mitochondrial Proteins - antagonists & inhibitors Mitochondrial Proteins - blood P-Selectin - blood Quinazolinones - pharmacology Rabbits Secretory Vesicles - drug effects Secretory Vesicles - metabolism Serotonin - blood Thrombosis - blood Thrombosis - etiology Thrombosis - prevention & control Time Factors Vascular System Injuries - blood Vascular System Injuries - etiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!