Synchronous solid neuroendocrine breast carcinoma and abdominal lymphoma: A case report and review of the literature
Neuroendocrine tumors (NETs) are frequently associated with second primary malignancies (SPMs). Earlier studies have demonstrated that NETs are highly associated with synchronous or metachronous gastrointestinal and genitourinary SPMs. We report, for the first time, a case of pure NE breast carcinom...
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| Veröffentlicht in: | Oncology letters 2013-02, Vol.5 (2), p.459-462 |
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| creator | ALONSO-RUANO, MIGUEL LÓPEZ-BONET, EUGENI HUERTA-ANAYA, MARIA VICTORIA VILA-CAMPS, ESTER BERNADÓ, LUIS TUCA-RODRÍGUEZ, FRANCESC SUAREZ-PUMARIEGA, PEDRO MENENDEZ, JAVIER A |
| description | Neuroendocrine tumors (NETs) are frequently associated with second primary malignancies (SPMs). Earlier studies have demonstrated that NETs are highly associated with synchronous or metachronous gastrointestinal and genitourinary SPMs. We report, for the first time, a case of pure NE breast carcinoma (NEBC) exhibiting all of the World Health Organization (WHO)-categorized morphological and phenotypic NE features (i.e., round solid nests of spindle cells, plasmacytoid cells, large clear or mucinous signet-ring cells with a peripheral palisading tendency and immunohistochemical positivity for the NE markers synaptophysin and chromogranin in more than 50% of the tumor cell population) along with synchronous abdominal non-Hodgkin's lymphoma. In the present study, we review the diagnosis, clinicopathological features and histogenetic profiling of NEBC and discuss the literature relevant to the clinical and anatomopathological management of this case. This previously unreported case of synchronous solid NEBC and abdominal lymphoma, together with earlier studies showing that primary symptoms are caused by SPMs in a significant subgroup of NET patients, strongly supports the notion that NETs should be cautiously considered to be index tumors. Therefore, risk-adapted clinicopathological follow-up with systematic investigation is strongly recommended. |
| doi_str_mv | 10.3892/ol.2012.1044 |
| format | Article |
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Earlier studies have demonstrated that NETs are highly associated with synchronous or metachronous gastrointestinal and genitourinary SPMs. We report, for the first time, a case of pure NE breast carcinoma (NEBC) exhibiting all of the World Health Organization (WHO)-categorized morphological and phenotypic NE features (i.e., round solid nests of spindle cells, plasmacytoid cells, large clear or mucinous signet-ring cells with a peripheral palisading tendency and immunohistochemical positivity for the NE markers synaptophysin and chromogranin in more than 50% of the tumor cell population) along with synchronous abdominal non-Hodgkin's lymphoma. In the present study, we review the diagnosis, clinicopathological features and histogenetic profiling of NEBC and discuss the literature relevant to the clinical and anatomopathological management of this case. This previously unreported case of synchronous solid NEBC and abdominal lymphoma, together with earlier studies showing that primary symptoms are caused by SPMs in a significant subgroup of NET patients, strongly supports the notion that NETs should be cautiously considered to be index tumors. Therefore, risk-adapted clinicopathological follow-up with systematic investigation is strongly recommended.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2012.1044</identifier><identifier>PMID: 23419985</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Abdomen ; Biopsy ; Breast cancer ; Case reports ; Chemotherapy ; Endocrine therapy ; Lymphatic system ; Lymphoma ; Medical imaging ; Medical prognosis ; Metastasis ; neuroendocrine breast carcinomas ; neuroendocrine tumors ; NMR ; Nuclear magnetic resonance ; Oncology ; Patients ; second primary malignancies ; Tumors</subject><ispartof>Oncology letters, 2013-02, Vol.5 (2), p.459-462</ispartof><rights>Copyright © 2013, Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2013</rights><rights>Copyright © 2013, Spandidos Publications 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-74b73d967ff5bfdc260a699d2efb617b719fdb5713baa0459a9aa0b5ea053cfb3</citedby><cites>FETCH-LOGICAL-c443t-74b73d967ff5bfdc260a699d2efb617b719fdb5713baa0459a9aa0b5ea053cfb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573045/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573045/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,5571,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23419985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ALONSO-RUANO, MIGUEL</creatorcontrib><creatorcontrib>LÓPEZ-BONET, EUGENI</creatorcontrib><creatorcontrib>HUERTA-ANAYA, MARIA VICTORIA</creatorcontrib><creatorcontrib>VILA-CAMPS, ESTER</creatorcontrib><creatorcontrib>BERNADÓ, LUIS</creatorcontrib><creatorcontrib>TUCA-RODRÍGUEZ, FRANCESC</creatorcontrib><creatorcontrib>SUAREZ-PUMARIEGA, PEDRO</creatorcontrib><creatorcontrib>MENENDEZ, JAVIER A</creatorcontrib><title>Synchronous solid neuroendocrine breast carcinoma and abdominal lymphoma: A case report and review of the literature</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>Neuroendocrine tumors (NETs) are frequently associated with second primary malignancies (SPMs). Earlier studies have demonstrated that NETs are highly associated with synchronous or metachronous gastrointestinal and genitourinary SPMs. We report, for the first time, a case of pure NE breast carcinoma (NEBC) exhibiting all of the World Health Organization (WHO)-categorized morphological and phenotypic NE features (i.e., round solid nests of spindle cells, plasmacytoid cells, large clear or mucinous signet-ring cells with a peripheral palisading tendency and immunohistochemical positivity for the NE markers synaptophysin and chromogranin in more than 50% of the tumor cell population) along with synchronous abdominal non-Hodgkin's lymphoma. In the present study, we review the diagnosis, clinicopathological features and histogenetic profiling of NEBC and discuss the literature relevant to the clinical and anatomopathological management of this case. This previously unreported case of synchronous solid NEBC and abdominal lymphoma, together with earlier studies showing that primary symptoms are caused by SPMs in a significant subgroup of NET patients, strongly supports the notion that NETs should be cautiously considered to be index tumors. Therefore, risk-adapted clinicopathological follow-up with systematic investigation is strongly recommended.</description><subject>Abdomen</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Endocrine therapy</subject><subject>Lymphatic system</subject><subject>Lymphoma</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>neuroendocrine breast carcinomas</subject><subject>neuroendocrine tumors</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oncology</subject><subject>Patients</subject><subject>second primary malignancies</subject><subject>Tumors</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkc1rFTEUxQex2FK7cy0BQVx0nvmYzExcFEqxKhS6UNchH3d8KZlkTGYq778301ef2tzFDTc_DrnnVNUrgjesF_R99BuKCd0Q3DTPqhPSCVoT3NPnh3vXHFdnOd_hcnhL-r59UR1T1hAhen5SzV93wWxTDHHJKEfvLAqwpAjBRpNcAKQTqDwjo5JxIY4KqWCR0jaOLiiP_G6ctmX8AV0WJgNKMMU0P1AJ7h38QnFA8xaQdzMkNS8JXlZHg_IZzh77afX9-uO3q8_1ze2nL1eXN7VpGjbXXaM7ZkXbDQPXgzW0xaoVwlIYdEs63RExWM07wrRSuOFCidI1B4U5M4Nmp9XFXnda9AjWQJiT8nJKblRpJ6Ny8v-X4LbyR7yXjHesCBaBd48CKf5cIM9ydNmA9ypAMUySnra8FGkL-uYJeheXVBwqlGC0paQnq-D5njIp5pxgOHyGYLkmKqOXa6JyTbTgr_9d4AD_ya8Ab_dAnorhzsb8dztfY15jWq_OsN-TSKty</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>ALONSO-RUANO, MIGUEL</creator><creator>LÓPEZ-BONET, EUGENI</creator><creator>HUERTA-ANAYA, MARIA VICTORIA</creator><creator>VILA-CAMPS, ESTER</creator><creator>BERNADÓ, LUIS</creator><creator>TUCA-RODRÍGUEZ, FRANCESC</creator><creator>SUAREZ-PUMARIEGA, PEDRO</creator><creator>MENENDEZ, JAVIER A</creator><general>D.A. 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Earlier studies have demonstrated that NETs are highly associated with synchronous or metachronous gastrointestinal and genitourinary SPMs. We report, for the first time, a case of pure NE breast carcinoma (NEBC) exhibiting all of the World Health Organization (WHO)-categorized morphological and phenotypic NE features (i.e., round solid nests of spindle cells, plasmacytoid cells, large clear or mucinous signet-ring cells with a peripheral palisading tendency and immunohistochemical positivity for the NE markers synaptophysin and chromogranin in more than 50% of the tumor cell population) along with synchronous abdominal non-Hodgkin's lymphoma. In the present study, we review the diagnosis, clinicopathological features and histogenetic profiling of NEBC and discuss the literature relevant to the clinical and anatomopathological management of this case. This previously unreported case of synchronous solid NEBC and abdominal lymphoma, together with earlier studies showing that primary symptoms are caused by SPMs in a significant subgroup of NET patients, strongly supports the notion that NETs should be cautiously considered to be index tumors. Therefore, risk-adapted clinicopathological follow-up with systematic investigation is strongly recommended.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>23419985</pmid><doi>10.3892/ol.2012.1044</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Oncology letters, 2013-02, Vol.5 (2), p.459-462 |
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| source | Spandidos Publications Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Abdomen Biopsy Breast cancer Case reports Chemotherapy Endocrine therapy Lymphatic system Lymphoma Medical imaging Medical prognosis Metastasis neuroendocrine breast carcinomas neuroendocrine tumors NMR Nuclear magnetic resonance Oncology Patients second primary malignancies Tumors |
| title | Synchronous solid neuroendocrine breast carcinoma and abdominal lymphoma: A case report and review of the literature |
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