Nutritional factors and gender influence age‐related DNA methylation in the human rectal mucosa

Summary Aberrant methylation of CpG islands (CGI) occurs in many genes expressed in colonic epithelial cells, and may contribute to the dysregulation of signalling pathways associated with carcinogenesis. This cross‐sectional study assessed the relative importance of age, nutritional exposures and o...

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Veröffentlicht in:	Aging cell 2013-02, Vol.12 (1), p.148-155
Hauptverfasser:	Tapp, Henri S., Commane, Daniel M., Bradburn, D. Michael, Arasaradnam, Ramesh, Mathers, John C., Johnson, Ian T., Belshaw, Nigel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Age Factors Aged aging colorectal cancer CpG Islands Deoxyribonucleic acid DNA DNA Methylation Feeding Behavior Female folate Folic Acid - blood Folic Acid - metabolism Humans Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Mucosa - physiology Leukocyte Count Male Middle Aged nutrition Original Rectum - metabolism Rectum - pathology Rectum - physiology Sex Factors Studies Young Adult
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