Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus

► Lack of CREB in PVN neurons leads to a significant increase of TRH expression. ► Lack of CREB in PVN neurons leads to a significant increase of CREM expression. ► Lack of CREB in PVN neurons does not affect regulation of TRH by thyroid hormones. ► CREM regulates TRH in vitro and in vivo. ► Regulat...

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Veröffentlicht in:	Molecular and cellular endocrinology 2013-01, Vol.365 (1), p.84-94
Hauptverfasser:	Chiappini, Franck, Ramadoss, Preeti, Vella, Kristen R., Cunha, Lucas L., Ye, Felix D., Stuart, Ronald C., Nillni, Eduardo A., Hollenberg, Anthony N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism binding proteins CREB CREM Cyclic AMP Response Element Modulator - genetics Cyclic AMP Response Element Modulator - metabolism Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Female gene expression gene expression regulation Gene Expression Regulation - drug effects HEK293 Cells Humans Hypothalamic-pituitary–thyroid axis Hypothalamo-Hypophyseal System - physiology hypothalamus Hypothalamus - cytology Hypothalamus - metabolism Hypothalamus - secretion Male messenger RNA Mice Mice, Knockout Mice, Transgenic Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - secretion neurons Neurons - cytology Neurons - metabolism Neurons - secretion Paraventricular Hypothalamic Nucleus - cytology Paraventricular Hypothalamic Nucleus - metabolism Paraventricular Hypothalamic Nucleus - secretion Pituitary-Adrenal System - physiology Recombinant Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Messenger - metabolism Thyroid hormone thyroid hormones thyrotropin thyrotropin-releasing hormone Thyrotropin-Releasing Hormone - genetics Thyrotropin-Releasing Hormone - metabolism Thyrotropin-Releasing Hormone - secretion TRH expression Triiodothyronine - metabolism
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