Uptake of 18F-Labeled 6-Fluoro-6-Deoxy-D-Glucose by Skeletal Muscle Is Responsive to Insulin Stimulation

We are developing a methodology for the noninvasive imaging of glucose transport in vivo with PET and (18)F-labeled 6-fluoro-6-deoxy-d-glucose ((18)F-6FDG), a tracer that is transported but not phosphorylated. To validate the method, we evaluated the biodistribution of (18)F-6FDG to test whether it...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2009-06, Vol.50 (6), p.912-919
Hauptverfasser:	Spring-Robinson, Chandra, Chandramouli, Visvanathan, Schumann, William C, Faulhaber, Peter F, Wang, Yanming, Wu, Chunying, Ismail-Beigi, Faramarz, Muzic, Raymond F., Jr
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Deoxyglucose - analogs & derivatives Deoxyglucose - pharmacokinetics Fluorine Radioisotopes Fluorodeoxyglucose F18 - pharmacokinetics Insulin - pharmacology Male Muscle, Skeletal - metabolism Rats Rats, Sprague-Dawley
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