A Single Dose of Any of Four Different Live Attenuated Tetravalent Dengue Vaccines Is Safe and Immunogenic in Flavivirus-naive Adults: A Randomized, Double-blind Clinical Trial

Background. Dengue virus (DENV) causes hundreds of millions of infections annually. Four dengue serotypes exist, and previous infection with one serotype increases the likelihood of severe disease with a second, heterotypic DENV infection. Methods. In a randomized, placebo-controlled study, the safe...

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Veröffentlicht in:	The Journal of infectious diseases 2013-03, Vol.207 (6), p.957-965
Hauptverfasser:	Durbin, Anna P., Kirkpatrick, Beth D., Pierce, Kristen K., Elwood, Daniel, Larsson, Catherine J., Lindow, Janet C., Tibery, Cecilia, Sabundayo, Beulah P., Shaffer, Donna, Talaat, Kawsar R., Hynes, Noreen A., Wanionek, Kimberli, Carmolli, Marya P., Luke, Catherine J., Murphy, Brian R., Subbarao, Kanta, Whitehead, Stephen S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Admixtures Adult American Indian or Alaska Native Antibodies, Viral - blood Black People Dengue Dengue - prevention & control Dengue vaccines Dengue Vaccines - administration & dosage Dengue Vaccines - adverse effects Dengue Vaccines - immunology Dengue virus Dengue Virus - immunology Dosage Double-Blind Method Exanthema Exanthema - virology Female Humans Immune response Infections Major and Brief Reports Male Native Hawaiian or Other Pacific Islander Vaccination Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - adverse effects Vaccines, Attenuated - immunology Viremia Viremia - virology Viruses White People Young Adult
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