Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells

Thymus-derived (natural) CD4(+) FoxP3(+) regulatory T cells (nT reg cells) are required for immune homeostasis and self-tolerance, but must be stringently controlled to permit expansion of protective immunity. Previous findings linking signals transmitted through T cell-expressed C5a receptor (C5aR)...

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Veröffentlicht in:	The Journal of experimental medicine 2013-02, Vol.210 (2), p.257-268
Hauptverfasser:	Kwan, Wing-hong, van der Touw, William, Paz-Artal, Estela, Li, Ming O, Heeger, Peter S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmune Diseases - prevention & control Colitis - immunology Colitis - pathology Colitis - prevention & control Forkhead Box Protein O1 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression Graft Rejection - immunology Graft Rejection - pathology Graft Rejection - prevention & control Immunity, Innate Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Proto-Oncogene Proteins c-akt - metabolism Receptor, Anaphylatoxin C5a - deficiency Receptor, Anaphylatoxin C5a - genetics Receptor, Anaphylatoxin C5a - metabolism Receptors, Complement - deficiency Receptors, Complement - genetics Receptors, Complement - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Signal Transduction - immunology Skin Transplantation - immunology Skin Transplantation - pathology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transplantation, Homologous
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