Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

Sepsis-induced organ failure is the major cause of death in critical care units, and is characterized by a massive dysregulated inflammatory response and oxidative stress. We investigated the effects of treatment with antioxidants that protect mitochondria (MitoQ, MitoE, or melatonin) in a rat model...

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Veröffentlicht in:British journal of anaesthesia : BJA 2013-03, Vol.110 (3), p.472-480
Hauptverfasser: Lowes, D.A., Webster, N.R., Murphy, M.P., Galley, H.F.
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Sprache:eng
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