The antidote effect of quinone oxidoreductase 2 inhibitor against paraquat‐induced toxicity in vitro and in vivo

BACKGROUND AND PURPOSE The mechanisms of paraquat (PQ)‐induced toxicity are poorly understood and PQ poisoning is often fatal due to a lack of effective antidotes. In this study we report the effects of N‐[2‐(2‐methoxy‐6H‐dipyrido{2,3‐a:3,2‐e}pyrrolizin‐11‐yl)ethyl]‐2‐furamide (NMDPEF), a melatonin‐...

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Veröffentlicht in:	British journal of pharmacology 2013-01, Vol.168 (1), p.46-59
Hauptverfasser:	Janda, Elzbieta, Parafati, Maddalena, Aprigliano, Serafina, Carresi, Cristina, Visalli, Valeria, Sacco, Iolanda, Ventrice, Domenica, Mega, Tiziana, Vadalá, Nuria, Rinaldi, Stefano, Musolino, Vincenzo, Palma, Ernesto, Gratteri, Santo, Rotiroti, Domenicantonio, Mollace, Vincenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar Epithelial Cells - drug effects Alveolar Epithelial Cells - pathology Animals Antidotes - pharmacology Apoptosis - drug effects astrocytes Astrocytes - drug effects Astrocytes - pathology Cells, Cultured electrocorticogram Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Gene Knockdown Techniques Herbicides - toxicity Humans Lung Neoplasms - metabolism Lung Neoplasms - pathology Malondialdehyde - metabolism mammary epithelial cells Mammary Glands, Human - metabolism Mammary Glands, Human - pathology Mice NQO2 oxidative stress Oxidative Stress - drug effects paraquat Paraquat - toxicity pesticides Quinone Reductases - antagonists & inhibitors Quinone Reductases - drug effects Quinone Reductases - genetics Quinone Reductases - metabolism Rats Rats, Wistar Reactive Oxygen Species - metabolism Research Papers with Commentaries ROS substantia nigra Substantia Nigra - drug effects Substantia Nigra - pathology
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