Synaptic Ribbons Influence the Size and Frequency of Miniature-like Evoked Postsynaptic Currents

Nonspiking cells of several sensory systems respond to stimuli with graded changes in neurotransmitter release and possess specialized synaptic ribbons. Here, we show that manipulations to synaptic ribbons caused dramatic effects on mEPSC-like (mlEPSC) amplitude and frequency. Damage to rod-bipolar...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2013-02, Vol.77 (3), p.516-527
Hauptverfasser:	Mehta, Bhupesh, Snellman, Josefin, Chen, Shan, Li, Wei, Zenisek, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminobutyrates - pharmacology Animals Biophysics DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Electric Stimulation Excitatory Amino Acid Agonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology GABA Antagonists - pharmacology Glycine Agents - pharmacology Hibernation - physiology In Vitro Techniques Mice Mice, Inbred C57BL Patch-Clamp Techniques Phosphinic Acids - pharmacology Phosphoproteins - metabolism Photoreceptors Picrotoxin - pharmacology Pyridines - pharmacology Receptors, AMPA - metabolism Retina Retina - cytology Retina - metabolism Sciuridae Software Spermophilus Strychnine - pharmacology Synapses - drug effects Synapses - physiology Visual Pathways - physiology Wakefulness - physiology
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