The N-terminal 20-Amino Acid Region of Guanine Nucleotide Exchange Factor Vav1 Plays a Distinguished Role in T Cell Receptor-mediated Calcium Signaling

Vav1 is a guanine nucleotide exchange factor (GEF) specifically expressed in hematopoietic cells. It consists of multiple structural domains and plays important roles in T cell activation. The other highly conserved isoforms of Vav family, Vav2 and Vav3, are ubiquitously expressed in human tissues i...

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Veröffentlicht in:	The Journal of biological chemistry 2013-02, Vol.288 (6), p.3777-3785
Hauptverfasser:	Li, Shi-Yang, Du, Ming-Juan, Wan, Ya-Juan, Lan, Bei, Liu, Yao-Hui, Yang, Yin, Zhang, Cui-Zhu, Cao, YouJia
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium Intracellular Release Calcium Signaling Calcium Signaling - physiology Calmodulin Calmodulin - genetics Calmodulin - metabolism Calmodulin-binding Proteins Guanine Nucleotide Exchange Factor (GEF) HeLa Cells Humans Interleukin-2 - biosynthesis Interleukin-2 - genetics Lymphocyte Activation - physiology Mutation NFAT Transcription Factor Protein Binding - physiology Protein Isoforms Protein Structure, Tertiary Proto-Oncogene Proteins c-vav - genetics Proto-Oncogene Proteins c-vav - metabolism Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Signal Transduction T Cell Biology T Cell Receptor T-Lymphocytes - cytology T-Lymphocytes - metabolism Vav1
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