Pseudomonas aeruginosa biofilms perturb wound resolution and antibiotic tolerance in diabetic mice

Diabetic patients are more susceptible to the development of chronic wounds than non-diabetics. The impaired healing properties of these wounds, which often develop debilitating bacterial infections, significantly increase the rate of lower extremity amputation in diabetic patients. We hypothesize t...

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Veröffentlicht in:	Medical microbiology and immunology 2013-04, Vol.202 (2), p.131-141
Hauptverfasser:	Watters, Chase, DeLeon, Katrina, Trivedi, Urvish, Griswold, John A., Lyte, Mark, Hampel, Ken J., Wargo, Matthew J., Rumbaugh, Kendra P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Bacteria Bacterial Adhesion Biofilms Biomedical and Life Sciences Biomedicine Chronic Disease Diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Drug Resistance, Bacterial Female Gene Expression Profiling Immunology Injuries Insulin Insulin - administration & dosage Insulin - pharmacology Medical Microbiology Mice Original Investigation Prevalence Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - physiology Rodents Virology Wound Healing Wound Infection - drug therapy Wound Infection - epidemiology Wound Infection - microbiology
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