Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations

Background: There are no reliable markers of malignancy in phaeochromocytomas (PCC) and paragangliomas (PGL). We investigated the relevance of the mammalian target of rapamycin (mTOR)/AKT and hypoxic pathways as novel immunohistochemical markers of malignancy. Methods: Tissue microarray blocks were...

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Veröffentlicht in:	British journal of cancer 2013-02, Vol.108 (2), p.429-437
Hauptverfasser:	Pinato, D J, Ramachandran, R, Toussi, S T K, Vergine, M, Ngo, N, Sharma, R, Lloyd, T, Meeran, K, Palazzo, F, Martin, N, Khoo, B, Dina, R, Tan, T M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/737 631/67/1857 692/699/67/1459/1963 Adrenal Gland Neoplasms - diagnosis Adrenal Gland Neoplasms - genetics Adrenal Gland Neoplasms - immunology Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adult Antigens, Neoplasm - analysis Antigens, Neoplasm - immunology Biological and medical sciences Biomarkers Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Biomarkers, Tumor - immunology Biomedical and Life Sciences Biomedicine Cancer Cancer Research Carbonic Anhydrase IX Carbonic Anhydrases - analysis Carbonic Anhydrases - immunology Catecholamines Cell Hypoxia Drug Resistance Endocrinopathies Epidemiology Female Germ-Line Mutation Hospitals Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - analysis Hypoxia-Inducible Factor 1, alpha Subunit - immunology Immunohistochemistry Male Medical sciences Metastasis Molecular Diagnostics Molecular Medicine Mutation Neoplasm Metastasis Non tumoral diseases. Target tissue resistance. Benign neoplasms Oncology Paraganglioma - chemistry Paraganglioma - diagnosis Paraganglioma - genetics Pheochromocytoma - chemistry Pheochromocytoma - diagnosis Pheochromocytoma - genetics Proto-Oncogene Proteins c-akt - analysis Proto-Oncogene Proteins c-akt - immunology Tissue Array Analysis TOR Serine-Threonine Kinases - analysis TOR Serine-Threonine Kinases - immunology Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - analysis Vascular Endothelial Growth Factor A - immunology von Hippel-Lindau Disease - diagnosis von Hippel-Lindau Disease - genetics Von Hippel-Lindau Tumor Suppressor Protein - genetics
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