Inhibition of GSK3 attenuates amphetamine-induced hyperactivity and sensitization in the mouse

► Amphetamine-induced hyperactivity was attenuated by valproate or SB 216763. ► Valproic acid increased GSK3 phosphorylation in amphetamine-treated mice. ► Valproic acid and SB 216763 attenuated the development of amphetamine-induced sensitization. ► We conclude that GSK3 activation is important for...

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Veröffentlicht in:	Behavioural brain research 2012-05, Vol.231 (1), p.217-225
Hauptverfasser:	Enman, Nicole M., Unterwald, Ellen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine Amphetamine - pharmacology Animals Brain - drug effects Brain - metabolism Central Nervous System Stimulants - pharmacology Glycogen Synthase Kinase 3 - antagonists & inhibitors GSK3 Hyperactivity Hyperkinesis - chemically induced Hyperkinesis - metabolism Indoles - pharmacology Male Maleimides - pharmacology Mice Motor Activity - drug effects Phosphorylation - drug effects Sensitization Stereotyped Behavior - drug effects
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