Absence of age-related prefrontal NAA change in adults with autism spectrum disorders
Atypical trajectory of brain growth in autism spectrum disorders (ASDs) has been recognized as a potential etiology of an atypical course of behavioral development. Numerous neuroimaging studies have focused on childhood to investigate atypical age-related change of brain structure and function, bec...
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| creator | Aoki, Y Abe, O Yahata, N Kuwabara, H Natsubori, T Iwashiro, N Takano, Y Inoue, H Kawakubo, Y Gonoi, W Sasaki, H Murakami, M Katsura, M Nippashi, Y Takao, H Kunimatsu, A Matsuzaki, H Tsuchiya, K J Kato, N Kasai, K Yamasue, H |
| description | Atypical trajectory of brain growth in autism spectrum disorders (ASDs) has been recognized as a potential etiology of an atypical course of behavioral development. Numerous neuroimaging studies have focused on childhood to investigate atypical age-related change of brain structure and function, because it is a period of neuron and synapse maturation. Recent studies, however, have shown that the atypical age-related structural change of autistic brain expands beyond childhood and constitutes neural underpinnings for lifelong difficulty to behavioral adaptation. Thus, we examined effects of aging on neurochemical aspects of brain maturation using 3-T proton magnetic resonance spectroscopy (
1
H-MRS) with single voxel in the medial prefrontal cortex (PFC) in 24 adult men with non-medicated high-functioning ASDs and 25 age-, IQ- and parental-socioeconomic-background-matched men with typical development (TD). Multivariate analyses of covariance demonstrated significantly high
N
-acetylaspartate (NAA) level in the ASD subjects compared with the TD subjects (F=4.83,
P
=0.033). The low NAA level showed a significant positive correlation with advanced age in the TD group (
r
=−0.618,
P
=0.001), but was not evident among the ASD individuals (
r
=0.258,
P
=0.223). Fisher’s
r
-to-
z
transformation showed a significant difference in the correlations between the ASD and TD groups (
Z
=−3.23,
P
=0.001), which indicated that the age–NAA relationship was significantly specific to people with TD. The current
1
H-MRS study provided new evidence that atypical age-related change of neurochemical aspects of brain maturation in ASD individuals expands beyond childhood and persists during adulthood. |
| doi_str_mv | 10.1038/tp.2012.108 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3565815</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1115063459</sourcerecordid><originalsourceid>FETCH-LOGICAL-c446t-11b133ae156098550db93ecdd7bc1d824079f8c1dc444073cdfd458c15600dba3</originalsourceid><addsrcrecordid>eNptkUFr3DAQhUVpaUKaU-9BkEuhcaqxLK98KSwhaQuhvTRnIUvjXQfbciS5pf8-s2waNqW66I3m42mkx9h7EJcgpP6U58tSQEmFfsWOS1C6kKD16wN9xE5Tuhe0VKVhBW_ZUSlFUza6PGZ36zbh5JCHjtsNFhEHm9HzOWIXw5TtwL-v19xt7bRB3k_c-mXIif_u85bbJfdp5GlGl-Myct-nED3G9I696eyQ8PRpP2F3N9c_r74Wtz--fLta3xauqupcALQgpUVQtWi0UsK3jUTn_ap14HVZiVXTaZKEk5bOd75SdEA8sVaesM9733lpR_QOpxztYObYjzb-McH25mVn6rdmE34ZqWqlQZHBhyeDGB4WTNmMfXI4DHbCsCQDAErUslINoef_oPdhiRM9z8CqAVlrkDvq455yMaREn_g8DAizS8zk2ewSo0ITfXY4_zP7Nx8CLvZAohYlEA8u_Y_fI4wmn7Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1791368139</pqid></control><display><type>article</type><title>Absence of age-related prefrontal NAA change in adults with autism spectrum disorders</title><source>MEDLINE</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Springer Nature OA Free Journals</source><creator>Aoki, Y ; Abe, O ; Yahata, N ; Kuwabara, H ; Natsubori, T ; Iwashiro, N ; Takano, Y ; Inoue, H ; Kawakubo, Y ; Gonoi, W ; Sasaki, H ; Murakami, M ; Katsura, M ; Nippashi, Y ; Takao, H ; Kunimatsu, A ; Matsuzaki, H ; Tsuchiya, K J ; Kato, N ; Kasai, K ; Yamasue, H</creator><creatorcontrib>Aoki, Y ; Abe, O ; Yahata, N ; Kuwabara, H ; Natsubori, T ; Iwashiro, N ; Takano, Y ; Inoue, H ; Kawakubo, Y ; Gonoi, W ; Sasaki, H ; Murakami, M ; Katsura, M ; Nippashi, Y ; Takao, H ; Kunimatsu, A ; Matsuzaki, H ; Tsuchiya, K J ; Kato, N ; Kasai, K ; Yamasue, H</creatorcontrib><description>Atypical trajectory of brain growth in autism spectrum disorders (ASDs) has been recognized as a potential etiology of an atypical course of behavioral development. Numerous neuroimaging studies have focused on childhood to investigate atypical age-related change of brain structure and function, because it is a period of neuron and synapse maturation. Recent studies, however, have shown that the atypical age-related structural change of autistic brain expands beyond childhood and constitutes neural underpinnings for lifelong difficulty to behavioral adaptation. Thus, we examined effects of aging on neurochemical aspects of brain maturation using 3-T proton magnetic resonance spectroscopy (
1
H-MRS) with single voxel in the medial prefrontal cortex (PFC) in 24 adult men with non-medicated high-functioning ASDs and 25 age-, IQ- and parental-socioeconomic-background-matched men with typical development (TD). Multivariate analyses of covariance demonstrated significantly high
N
-acetylaspartate (NAA) level in the ASD subjects compared with the TD subjects (F=4.83,
P
=0.033). The low NAA level showed a significant positive correlation with advanced age in the TD group (
r
=−0.618,
P
=0.001), but was not evident among the ASD individuals (
r
=0.258,
P
=0.223). Fisher’s
r
-to-
z
transformation showed a significant difference in the correlations between the ASD and TD groups (
Z
=−3.23,
P
=0.001), which indicated that the age–NAA relationship was significantly specific to people with TD. The current
1
H-MRS study provided new evidence that atypical age-related change of neurochemical aspects of brain maturation in ASD individuals expands beyond childhood and persists during adulthood.</description><identifier>ISSN: 2158-3188</identifier><identifier>EISSN: 2158-3188</identifier><identifier>DOI: 10.1038/tp.2012.108</identifier><identifier>PMID: 23092982</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/136/7 ; 631/378/1689/1373 ; 631/45/882 ; 692/700/1421/65 ; Adult ; Age Factors ; Aging - metabolism ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Asperger Syndrome - metabolism ; Autistic Disorder - metabolism ; Behavioral Sciences ; Biological Psychology ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Medicine ; Medicine & Public Health ; Multivariate Analysis ; Neurosciences ; Original ; original-article ; Pharmacotherapy ; Prefrontal Cortex - metabolism ; Psychiatry</subject><ispartof>Translational psychiatry, 2012-10, Vol.2 (10), p.e178-e178</ispartof><rights>The Author(s) 2012</rights><rights>Copyright Nature Publishing Group Oct 2012</rights><rights>Copyright © 2012 Macmillan Publishers Limited 2012 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-11b133ae156098550db93ecdd7bc1d824079f8c1dc444073cdfd458c15600dba3</citedby><cites>FETCH-LOGICAL-c446t-11b133ae156098550db93ecdd7bc1d824079f8c1dc444073cdfd458c15600dba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565815/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565815/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23092982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aoki, Y</creatorcontrib><creatorcontrib>Abe, O</creatorcontrib><creatorcontrib>Yahata, N</creatorcontrib><creatorcontrib>Kuwabara, H</creatorcontrib><creatorcontrib>Natsubori, T</creatorcontrib><creatorcontrib>Iwashiro, N</creatorcontrib><creatorcontrib>Takano, Y</creatorcontrib><creatorcontrib>Inoue, H</creatorcontrib><creatorcontrib>Kawakubo, Y</creatorcontrib><creatorcontrib>Gonoi, W</creatorcontrib><creatorcontrib>Sasaki, H</creatorcontrib><creatorcontrib>Murakami, M</creatorcontrib><creatorcontrib>Katsura, M</creatorcontrib><creatorcontrib>Nippashi, Y</creatorcontrib><creatorcontrib>Takao, H</creatorcontrib><creatorcontrib>Kunimatsu, A</creatorcontrib><creatorcontrib>Matsuzaki, H</creatorcontrib><creatorcontrib>Tsuchiya, K J</creatorcontrib><creatorcontrib>Kato, N</creatorcontrib><creatorcontrib>Kasai, K</creatorcontrib><creatorcontrib>Yamasue, H</creatorcontrib><title>Absence of age-related prefrontal NAA change in adults with autism spectrum disorders</title><title>Translational psychiatry</title><addtitle>Transl Psychiatry</addtitle><addtitle>Transl Psychiatry</addtitle><description>Atypical trajectory of brain growth in autism spectrum disorders (ASDs) has been recognized as a potential etiology of an atypical course of behavioral development. Numerous neuroimaging studies have focused on childhood to investigate atypical age-related change of brain structure and function, because it is a period of neuron and synapse maturation. Recent studies, however, have shown that the atypical age-related structural change of autistic brain expands beyond childhood and constitutes neural underpinnings for lifelong difficulty to behavioral adaptation. Thus, we examined effects of aging on neurochemical aspects of brain maturation using 3-T proton magnetic resonance spectroscopy (
1
H-MRS) with single voxel in the medial prefrontal cortex (PFC) in 24 adult men with non-medicated high-functioning ASDs and 25 age-, IQ- and parental-socioeconomic-background-matched men with typical development (TD). Multivariate analyses of covariance demonstrated significantly high
N
-acetylaspartate (NAA) level in the ASD subjects compared with the TD subjects (F=4.83,
P
=0.033). The low NAA level showed a significant positive correlation with advanced age in the TD group (
r
=−0.618,
P
=0.001), but was not evident among the ASD individuals (
r
=0.258,
P
=0.223). Fisher’s
r
-to-
z
transformation showed a significant difference in the correlations between the ASD and TD groups (
Z
=−3.23,
P
=0.001), which indicated that the age–NAA relationship was significantly specific to people with TD. The current
1
H-MRS study provided new evidence that atypical age-related change of neurochemical aspects of brain maturation in ASD individuals expands beyond childhood and persists during adulthood.</description><subject>631/136/7</subject><subject>631/378/1689/1373</subject><subject>631/45/882</subject><subject>692/700/1421/65</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aging - metabolism</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Asperger Syndrome - metabolism</subject><subject>Autistic Disorder - metabolism</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate Analysis</subject><subject>Neurosciences</subject><subject>Original</subject><subject>original-article</subject><subject>Pharmacotherapy</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Psychiatry</subject><issn>2158-3188</issn><issn>2158-3188</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkUFr3DAQhUVpaUKaU-9BkEuhcaqxLK98KSwhaQuhvTRnIUvjXQfbciS5pf8-s2waNqW66I3m42mkx9h7EJcgpP6U58tSQEmFfsWOS1C6kKD16wN9xE5Tuhe0VKVhBW_ZUSlFUza6PGZ36zbh5JCHjtsNFhEHm9HzOWIXw5TtwL-v19xt7bRB3k_c-mXIif_u85bbJfdp5GlGl-Myct-nED3G9I696eyQ8PRpP2F3N9c_r74Wtz--fLta3xauqupcALQgpUVQtWi0UsK3jUTn_ap14HVZiVXTaZKEk5bOd75SdEA8sVaesM9733lpR_QOpxztYObYjzb-McH25mVn6rdmE34ZqWqlQZHBhyeDGB4WTNmMfXI4DHbCsCQDAErUslINoef_oPdhiRM9z8CqAVlrkDvq455yMaREn_g8DAizS8zk2ewSo0ITfXY4_zP7Nx8CLvZAohYlEA8u_Y_fI4wmn7Q</recordid><startdate>20121023</startdate><enddate>20121023</enddate><creator>Aoki, Y</creator><creator>Abe, O</creator><creator>Yahata, N</creator><creator>Kuwabara, H</creator><creator>Natsubori, T</creator><creator>Iwashiro, N</creator><creator>Takano, Y</creator><creator>Inoue, H</creator><creator>Kawakubo, Y</creator><creator>Gonoi, W</creator><creator>Sasaki, H</creator><creator>Murakami, M</creator><creator>Katsura, M</creator><creator>Nippashi, Y</creator><creator>Takao, H</creator><creator>Kunimatsu, A</creator><creator>Matsuzaki, H</creator><creator>Tsuchiya, K J</creator><creator>Kato, N</creator><creator>Kasai, K</creator><creator>Yamasue, H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121023</creationdate><title>Absence of age-related prefrontal NAA change in adults with autism spectrum disorders</title><author>Aoki, Y ; Abe, O ; Yahata, N ; Kuwabara, H ; Natsubori, T ; Iwashiro, N ; Takano, Y ; Inoue, H ; Kawakubo, Y ; Gonoi, W ; Sasaki, H ; Murakami, M ; Katsura, M ; Nippashi, Y ; Takao, H ; Kunimatsu, A ; Matsuzaki, H ; Tsuchiya, K J ; Kato, N ; Kasai, K ; Yamasue, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-11b133ae156098550db93ecdd7bc1d824079f8c1dc444073cdfd458c15600dba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>631/136/7</topic><topic>631/378/1689/1373</topic><topic>631/45/882</topic><topic>692/700/1421/65</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aging - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aoki, Y</au><au>Abe, O</au><au>Yahata, N</au><au>Kuwabara, H</au><au>Natsubori, T</au><au>Iwashiro, N</au><au>Takano, Y</au><au>Inoue, H</au><au>Kawakubo, Y</au><au>Gonoi, W</au><au>Sasaki, H</au><au>Murakami, M</au><au>Katsura, M</au><au>Nippashi, Y</au><au>Takao, H</au><au>Kunimatsu, A</au><au>Matsuzaki, H</au><au>Tsuchiya, K J</au><au>Kato, N</au><au>Kasai, K</au><au>Yamasue, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Absence of age-related prefrontal NAA change in adults with autism spectrum disorders</atitle><jtitle>Translational psychiatry</jtitle><stitle>Transl Psychiatry</stitle><addtitle>Transl Psychiatry</addtitle><date>2012-10-23</date><risdate>2012</risdate><volume>2</volume><issue>10</issue><spage>e178</spage><epage>e178</epage><pages>e178-e178</pages><issn>2158-3188</issn><eissn>2158-3188</eissn><abstract>Atypical trajectory of brain growth in autism spectrum disorders (ASDs) has been recognized as a potential etiology of an atypical course of behavioral development. Numerous neuroimaging studies have focused on childhood to investigate atypical age-related change of brain structure and function, because it is a period of neuron and synapse maturation. Recent studies, however, have shown that the atypical age-related structural change of autistic brain expands beyond childhood and constitutes neural underpinnings for lifelong difficulty to behavioral adaptation. Thus, we examined effects of aging on neurochemical aspects of brain maturation using 3-T proton magnetic resonance spectroscopy (
1
H-MRS) with single voxel in the medial prefrontal cortex (PFC) in 24 adult men with non-medicated high-functioning ASDs and 25 age-, IQ- and parental-socioeconomic-background-matched men with typical development (TD). Multivariate analyses of covariance demonstrated significantly high
N
-acetylaspartate (NAA) level in the ASD subjects compared with the TD subjects (F=4.83,
P
=0.033). The low NAA level showed a significant positive correlation with advanced age in the TD group (
r
=−0.618,
P
=0.001), but was not evident among the ASD individuals (
r
=0.258,
P
=0.223). Fisher’s
r
-to-
z
transformation showed a significant difference in the correlations between the ASD and TD groups (
Z
=−3.23,
P
=0.001), which indicated that the age–NAA relationship was significantly specific to people with TD. The current
1
H-MRS study provided new evidence that atypical age-related change of neurochemical aspects of brain maturation in ASD individuals expands beyond childhood and persists during adulthood.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23092982</pmid><doi>10.1038/tp.2012.108</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Springer Nature OA Free Journals |
| subjects | 631/136/7 631/378/1689/1373 631/45/882 692/700/1421/65 Adult Age Factors Aging - metabolism Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Asperger Syndrome - metabolism Autistic Disorder - metabolism Behavioral Sciences Biological Psychology Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Medicine Medicine & Public Health Multivariate Analysis Neurosciences Original original-article Pharmacotherapy Prefrontal Cortex - metabolism Psychiatry |
| title | Absence of age-related prefrontal NAA change in adults with autism spectrum disorders |
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