Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice

Acute ultraviolet (UV) B exposure causes photokeratitis and induces apoptosis in corneal cells. Geranylgeranylacetone (GGA) is an acyclic polyisoprenoid that induces expression of heat shock protein (HSP)70, a soluble intracellular chaperone protein expressed in various tissues, protecting cells aga...

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Veröffentlicht in:	International journal of molecular sciences 2013-01, Vol.14 (1), p.2175-2189
Hauptverfasser:	Lennikov, Anton, Kitaichi, Nobuyoshi, Kase, Satoru, Noda, Kousuke, Horie, Yukihiro, Nakai, Akira, Ohno, Shigeaki, Ishida, Susumu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - radiation effects Cornea Cornea - metabolism Cornea - pathology Diterpenes - pharmacology Heat shock proteins HSP70 Heat-Shock Proteins - biosynthesis Keratitis - metabolism Keratitis - pathology Keratitis - prevention & control Kinases Labeling Male Mice NF-kappa B - metabolism Ophthalmology Proto-Oncogene Proteins c-akt - metabolism Reactive Oxygen Species - metabolism Ultraviolet Rays - adverse effects
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