Role of oxidative stress in refractory epilepsy: evidence in patients and experimental models
Oxidative stress, a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with systemic diseases, and diseases affecting the central nervous system. Epilepsy is a chronic neurological disorder with...
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| Veröffentlicht in: | International journal of molecular sciences 2013-01, Vol.14 (1), p.1455-1476 |
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| container_title | International journal of molecular sciences |
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| creator | Cardenas-Rodriguez, Noemi Huerta-Gertrudis, Bernardino Rivera-Espinosa, Liliana Montesinos-Correa, Hortencia Bandala, Cindy Carmona-Aparicio, Liliana Coballase-Urrutia, Elvia |
| description | Oxidative stress, a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with systemic diseases, and diseases affecting the central nervous system. Epilepsy is a chronic neurological disorder with refractoriness to drug therapy at about 30%. Currently, experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy. Hence, the aim of this review is to present information in order to facilitate the handling of this evidence and determine the therapeutic impact of the biochemical status for this pathology. |
| doi_str_mv | 10.3390/ijms14011455 |
| format | Article |
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Hence, the aim of this review is to present information in order to facilitate the handling of this evidence and determine the therapeutic impact of the biochemical status for this pathology.</description><subject>Animals</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Antioxidants - metabolism</subject><subject>Disease Models, Animal</subject><subject>Drug Resistance</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - metabolism</subject><subject>Humans</subject><subject>Oxidative Stress</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Review</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc1r3DAQxUVpaL5667kIeskhm2pGkr3uIRBCviAQKMkxCEUet1psy5W8S_a_j5Zslm0uOWlG89PjaR5j30CcSFmJn37WJVACQGn9ie2BQpwIUZSft-pdtp_STAiUqKsvbBelVEpo3GOPv0NLPDQ8PPvajn5BPI2RUuK-55GaaN0Y4pLT4Fsa0vIXp4WvqXe0Aob8gvoxcdvXnJ4Hir7LvW15F2pq0yHbaWyb6Ov6PGAPlxf359eT27urm_Oz24lTSo-TEkmjg6KiyrpaTYuqkRYx97bMF7qQ2jWlJXAVlFjTFAXIAqxzTuqnBuUBO33VHeZPHdUue4i2NUO2Y-PSBOvN_5Pe_zV_wsJIXWgpRRY4WgvE8G9OaTSdT47a1vYU5smAgkqWIEr4GMVsT-G0VBn98Q6dhXns8yYMaCwEaqhWgsevlIshpbzzjW8QZhWx2Y4449-3_7qB3zKVL7JIo04</recordid><startdate>20130114</startdate><enddate>20130114</enddate><creator>Cardenas-Rodriguez, Noemi</creator><creator>Huerta-Gertrudis, Bernardino</creator><creator>Rivera-Espinosa, Liliana</creator><creator>Montesinos-Correa, Hortencia</creator><creator>Bandala, Cindy</creator><creator>Carmona-Aparicio, Liliana</creator><creator>Coballase-Urrutia, Elvia</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6580-3440</orcidid></search><sort><creationdate>20130114</creationdate><title>Role of oxidative stress in refractory epilepsy: evidence in patients and experimental models</title><author>Cardenas-Rodriguez, Noemi ; 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| subjects | Animals Anticonvulsants - therapeutic use Antioxidants - metabolism Disease Models, Animal Drug Resistance Epilepsy - drug therapy Epilepsy - metabolism Humans Oxidative Stress Reactive Oxygen Species - metabolism Review |
| title | Role of oxidative stress in refractory epilepsy: evidence in patients and experimental models |
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