Amyloid plaque pathogenesis in 5XFAD mouse spinal cord: retrograde transneuronal modulation after peripheral nerve injury

The spinal cord is composed of distinct neuronal groups with well-defined anatomic connections. In some transgenic (Tg) models of Alzheimer’s disease (AD), amyloid plaques develop in this structure, although the underlying cellular mechanism remains elusive. We attempted to explore the origin, evolu...

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Veröffentlicht in:	Neurotoxicity research 2013-07, Vol.24 (1), p.1-14
Hauptverfasser:	Li, Jian-Ming, Xue, Zhi-Qin, Deng, Si-Hao, Luo, Xue-Gang, Patrylo, Peter R., Rose, Gregory W., Cai, Huaibin, Cai, Yan, Yan, Xiao-Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases - metabolism Animals Biomedical and Life Sciences Biomedicine Cell Biology DNA-Binding Proteins Male Mice Mice, Transgenic Nerve Tissue Proteins - metabolism Neurobiology Neurochemistry Neurology Neurosciences Nuclear Proteins - metabolism Original Article Peripheral Nerve Injuries - metabolism Peripheral Nerve Injuries - pathology Pharmacology/Toxicology Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Presynaptic Terminals - metabolism Presynaptic Terminals - pathology Retrograde Degeneration Sciatic Nerve - injuries Spinal Cord - metabolism Spinal Cord - pathology Synaptophysin - metabolism Vesicular Glutamate Transport Protein 1 - metabolism
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