Individualized, discrete event, simulations provide insight into inter- and intra-subject variability of extended-release, drug products

Develop and validate particular, concrete, and abstract yet plausible in silico mechanistic explanations for large intra- and interindividual variability observed for eleven bioequivalence study participants. Do so in the face of considerable uncertainty about mechanisms. We constructed an object-or...

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Veröffentlicht in:	Theoretical biology and medical modelling 2012-08, Vol.9 (1), p.39-39, Article 39
Hauptverfasser:	Kim, Sean H J, Jackson, Andre J, Hur, Rim, Hunt, C Anthony
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological Availability Computer Simulation Delayed-Action Preparations - pharmacokinetics Delayed-Action Preparations - pharmacology Drugs Gastrointestinal system Gastrointestinal Tract - drug effects Humans Pharmaceutical Preparations - metabolism Physiological aspects Software Testing equipment Therapeutic Equivalency
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