Gene Loops Enhance Transcriptional Directionality

Eukaryotic genomes are extensively transcribed, forming both messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs). ncRNAs made by RNA polymerase II often initiate from bidirectional promoters (nucleosome-depleted chromatin) that synthesize mRNA and ncRNA in opposite directions. We demonstrate that, by...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2012-11, Vol.338 (6107), p.671-675
Hauptverfasser:	Tan-Wong, Sue Mei, Zaugg, Judith B., Camblong, Jurgi, Xu, Zhenyu, Zhang, David W., Mischo, Hannah E., Ansari, Aseem Z., Luscombe, Nicholas M., Steinmetz, Lars M., Proudfoot, Nick J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Analytical, structural and metabolic biochemistry Bidirectional Biological and medical sciences Biosynthesis Chromatin Coding DNA-directed RNA polymerase Eukaryotes Exosome Multienzyme Ribonuclease Complex - metabolism Formations Fundamental and applied biological sciences. Psychology Genes Genes, Fungal Genetic mutation Genome, Fungal Genomes Histones Messenger RNA Molecular and cellular biology Molecular genetics mRNA Cleavage and Polyadenylation Factors - metabolism Mutagenesis Mutation Nucleic Acid Conformation Online Open reading frames Phosphoprotein Phosphatases - metabolism Promoter regions Promoter Regions, Genetic Ribonucleic acids RNA RNA polymerase RNA polymerase II RNA Polymerase II - metabolism RNA Stability RNA, Fungal - genetics RNA, Fungal - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Untranslated - genetics RNA, Untranslated - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism transcription (genetics) Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing
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