A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer

Julius Gudmundsson, Kari Stefansson and colleagues identify a low-frequency variant at 8q24 strongly associated with prostate cancer risk. They also confirm association of a recently reported risk variant in HOXB13 in samples from multiple European populations. In Western countries, prostate cancer...

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Veröffentlicht in:	Nature genetics 2012-12, Vol.44 (12), p.1326-1329
Hauptverfasser:	Gudmundsson, Julius, Sulem, Patrick, Gudbjartsson, Daniel F, Masson, Gisli, Agnarsson, Bjarni A, Benediktsdottir, Kristrun R, Sigurdsson, Asgeir, Magnusson, Olafur Th, Gudjonsson, Sigurjon A, Magnusdottir, Droplaug N, Johannsdottir, Hrefna, Helgadottir, Hafdis Th, Stacey, Simon N, Jonasdottir, Adalbjorg, Olafsdottir, Stefania B, Thorleifsson, Gudmar, Jonasson, Jon G, Tryggvadottir, Laufey, Navarrete, Sebastian, Fuertes, Fernando, Helfand, Brian T, Hu, Qiaoyan, Csiki, Irma E, Mates, Ioan N, Jinga, Viorel, Aben, Katja K H, van Oort, Inge M, Vermeulen, Sita H, Donovan, Jenny L, Hamdy, Freddy C, Ng, Chi-Fai, Chiu, Peter K F, Lau, Kin-Mang, Ng, Maggie C Y, Gulcher, Jeffrey R, Kong, Augustine, Catalona, William J, Mayordomo, Jose I, Einarsson, Gudmundur V, Barkardottir, Rosa B, Jonsson, Eirikur, Mates, Dana, Neal, David E, Kiemeney, Lambertus A, Thorsteinsdottir, Unnur, Rafnar, Thorunn, Stefansson, Kari
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/205 631/208/726/649/2219 631/67/589/466 Adenocarcinoma - genetics Aged Aged, 80 and over Agriculture Animal Genetics and Genomics Base Sequence Biological and medical sciences Biomedicine Cancer Research Cell Line Chromosomes, Human, Pair 8 Classical genetics, quantitative genetics, hybrids Diagnosis DNA sequencing European Continental Ancestry Group - genetics Family medical history Fundamental and applied biological sciences. Psychology Gene Frequency Gene Function Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genome, Human Genome-Wide Association Study Genomes Gynecology. Andrology. Obstetrics Health risks Homeodomain Proteins - genetics Human Genetics Humans Iceland letter Logistics Male Male genital diseases Medical research Medical sciences Men Methods, theories and miscellaneous Middle Aged Molecular Sequence Data Mutation Nephrology. Urinary tract diseases Nucleotide sequencing Polymorphism, Single Nucleotide Prostate cancer Prostatic Neoplasms - genetics Risk Risk factors Sequence Analysis, DNA Single nucleotide polymorphisms Studies Tumors Tumors of the urinary system Urinary tract. Prostate gland
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