Mechanism and function of Vav1 localisation in TCR signalling

The antigen-specific binding of T cells to antigen presenting cells results in recruitment of signalling proteins to microclusters at the cell-cell interface known as the immunological synapse (IS). The Vav1 guanine nucleotide exchange factor plays a critical role in T cell antigen receptor (TCR) si...

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Veröffentlicht in:	Journal of cell science 2012-11, Vol.125 (Pt 22), p.5302-5314
Hauptverfasser:	Ksionda, Olga, Saveliev, Alexander, Köchl, Robert, Rapley, Jonathan, Faroudi, Mustapha, Smith-Garvin, Jennifer E, Wülfing, Christoph, Rittinger, Katrin, Carter, Tom, Tybulewicz, Victor L J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - metabolism Cells, Cultured Humans Immunological Synapses - metabolism Mice Mutant Proteins - chemistry Mutant Proteins - metabolism Phosphorylation Protein Transport - immunology Proto-Oncogene Proteins c-vav - chemistry Proto-Oncogene Proteins c-vav - metabolism Receptors, Antigen, T-Cell - metabolism Signal Transduction - immunology src Homology Domains
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