Alzheimer's disease and insulin resistance: translating basic science into clinical applications

Alzheimer's disease (AD) and diabetes are currently considered among the top threats to human health worldwide. Intriguingly, a connection between these diseases has been established during the past decade, since insulin resistance, a hallmark of type 2 diabetes, also develops in Alzheimer brai...

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Veröffentlicht in:	The Journal of clinical investigation 2013-02, Vol.123 (2), p.531-539
1. Verfasser:	De Felice, Fernanda G
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - etiology Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - physiology Amyloid beta-Peptides - toxicity Animals Biomedical research Brain Brain - drug effects Brain - physiopathology Care and treatment Cellular signal transduction Complications and side effects Development and progression Diabetes Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - physiopathology Disease Genetic aspects Humans Hypothalamus Insulin Receptor Substrate Proteins - physiology Insulin resistance Insulin Resistance - physiology Insulin-Like Growth Factor I - physiology Memory Models, Neurological Neurotoxins - metabolism Neurotoxins - toxicity Oxidative Stress Peptides Physiological aspects Receptor, Insulin - drug effects Receptor, Insulin - physiology Science in Medicine Signal Transduction - drug effects Translational Medical Research
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