Xerogel Optical Sensor Films for Quantitative Detection of Nitroxyl
Xerogel sensing films synthesized via sol−gel chemistry were used to fabricate optical nitroxyl (HNO) sensors. Selective detection of HNO in solution was achieved by monitoring the rates of manganese(III) meso-tetrakis(4-sulfonatophenyl) porphyrinate (MnIIITPPS) reductive nitrosylation in the anaero...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2008-02, Vol.80 (4), p.1247-1254 |
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| creator | Dobmeier, Kevin P Riccio, Daniel A Schoenfisch, Mark H |
| description | Xerogel sensing films synthesized via sol−gel chemistry were used to fabricate optical nitroxyl (HNO) sensors. Selective detection of HNO in solution was achieved by monitoring the rates of manganese(III) meso-tetrakis(4-sulfonatophenyl) porphyrinate (MnIIITPPS) reductive nitrosylation in the anaerobic interior of aminoalkoxysilane-derived xerogel films. Nitroxyl permeability in sensor films deposited in round-bottom 96-well plates was enhanced via incorporation of trimethoxysilyl-terminated poly(amidoamine-organosilicon) dendrimers in the xerogel network. The selectivity of MnIIITPPS for HNO, the overall sensitivity, and the working dynamic range of the resulting sensors were characterized. The HNO-sensing microtiter plates were used to quantify pH-dependent HNO generation by the recently described HNO-donor sodium 1-(isopropylamino)diazene-1-ium-1,2-diolate (IPA/NO), and compare HNO production efficiency between IPA/NO and Angeli's salt, a traditional HNO-donor. |
| doi_str_mv | 10.1021/ac702024t |
| format | Article |
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Selective detection of HNO in solution was achieved by monitoring the rates of manganese(III) meso-tetrakis(4-sulfonatophenyl) porphyrinate (MnIIITPPS) reductive nitrosylation in the anaerobic interior of aminoalkoxysilane-derived xerogel films. Nitroxyl permeability in sensor films deposited in round-bottom 96-well plates was enhanced via incorporation of trimethoxysilyl-terminated poly(amidoamine-organosilicon) dendrimers in the xerogel network. The selectivity of MnIIITPPS for HNO, the overall sensitivity, and the working dynamic range of the resulting sensors were characterized. The HNO-sensing microtiter plates were used to quantify pH-dependent HNO generation by the recently described HNO-donor sodium 1-(isopropylamino)diazene-1-ium-1,2-diolate (IPA/NO), and compare HNO production efficiency between IPA/NO and Angeli's salt, a traditional HNO-donor.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/ac702024t</identifier><identifier>PMID: 18197695</identifier><identifier>CODEN: ANCHAM</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Acids ; Analytical chemistry ; Biosensing Techniques - methods ; Chemistry ; Exact sciences and technology ; Gels - chemistry ; General, instrumentation ; Hydrogen-Ion Concentration ; Kinetics ; Manganese - chemistry ; Manganese compounds ; Neuroprotective Agents - analysis ; Nitric oxide ; Nitrogen Oxides - analysis ; Optics and Photonics ; Organometallic Compounds - chemistry ; Organosilicon Compounds - chemistry ; Porphyrins - chemistry ; Sensitivity and Specificity ; Sensors ; Silicon Dioxide - chemistry</subject><ispartof>Analytical chemistry (Washington), 2008-02, Vol.80 (4), p.1247-1254</ispartof><rights>Copyright © 2008 American Chemical Society</rights><rights>2008 INIST-CNRS</rights><rights>Copyright American Chemical Society Feb 15, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a498t-f2432e00a50f76f502de15014a7f13132076960a49357637821381083451e0cc3</citedby><cites>FETCH-LOGICAL-a498t-f2432e00a50f76f502de15014a7f13132076960a49357637821381083451e0cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ac702024t$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ac702024t$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,780,784,885,2763,27075,27923,27924,56737,56787</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20143543$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18197695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dobmeier, Kevin P</creatorcontrib><creatorcontrib>Riccio, Daniel A</creatorcontrib><creatorcontrib>Schoenfisch, Mark H</creatorcontrib><title>Xerogel Optical Sensor Films for Quantitative Detection of Nitroxyl</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>Xerogel sensing films synthesized via sol−gel chemistry were used to fabricate optical nitroxyl (HNO) sensors. Selective detection of HNO in solution was achieved by monitoring the rates of manganese(III) meso-tetrakis(4-sulfonatophenyl) porphyrinate (MnIIITPPS) reductive nitrosylation in the anaerobic interior of aminoalkoxysilane-derived xerogel films. Nitroxyl permeability in sensor films deposited in round-bottom 96-well plates was enhanced via incorporation of trimethoxysilyl-terminated poly(amidoamine-organosilicon) dendrimers in the xerogel network. The selectivity of MnIIITPPS for HNO, the overall sensitivity, and the working dynamic range of the resulting sensors were characterized. The HNO-sensing microtiter plates were used to quantify pH-dependent HNO generation by the recently described HNO-donor sodium 1-(isopropylamino)diazene-1-ium-1,2-diolate (IPA/NO), and compare HNO production efficiency between IPA/NO and Angeli's salt, a traditional HNO-donor.</description><subject>Acids</subject><subject>Analytical chemistry</subject><subject>Biosensing Techniques - methods</subject><subject>Chemistry</subject><subject>Exact sciences and technology</subject><subject>Gels - chemistry</subject><subject>General, instrumentation</subject><subject>Hydrogen-Ion Concentration</subject><subject>Kinetics</subject><subject>Manganese - chemistry</subject><subject>Manganese compounds</subject><subject>Neuroprotective Agents - analysis</subject><subject>Nitric oxide</subject><subject>Nitrogen Oxides - analysis</subject><subject>Optics and Photonics</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organosilicon Compounds - chemistry</subject><subject>Porphyrins - chemistry</subject><subject>Sensitivity and Specificity</subject><subject>Sensors</subject><subject>Silicon Dioxide - chemistry</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkV1rVDEQhoModlu98A_IQVDw4tSZ5ORjbwRZu610sUorehdimtTUsydrklPaf2_KLrt-XM3APLzzzryEPEM4RKD4xlgJFGhXHpAJcgqtUIo-JBMAYC2VAHtkP-drAERA8ZjsocKpFFM-IbNvLsUr1zdnqxKs6ZtzN-SYmnnol7nxtfs8mqGEYkq4cc17V5wtIQ5N9M3HUFK8veufkEfe9Nk93dQD8mV-dDE7aRdnxx9m7xat6aaqtJ52jDoAw8FL4TnQS4ccsDPSI0NGoVoSUGHGpWBSUWQKQbGOowNr2QF5u9Zdjd-X7tK6oSTT61UKS5PudDRB_z0Zwg99FW804wKrdhV4tRFI8dfoctHLkK3rezO4OGZdv1h3c1nBF_-A13FMQz1OU5RKcUZphV6vIZtizsn5rRMEfZ-L3uZS2ed_Wt-RmyAq8HIDmFxj8MkMNuQtR-ubGO9Y5do1F3Jxt9u5ST-1kExyffHpXJ-I0_nXBcw17HSNzbsj_jf4G5pjrfM</recordid><startdate>20080215</startdate><enddate>20080215</enddate><creator>Dobmeier, Kevin P</creator><creator>Riccio, Daniel A</creator><creator>Schoenfisch, Mark H</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080215</creationdate><title>Xerogel Optical Sensor Films for Quantitative Detection of Nitroxyl</title><author>Dobmeier, Kevin P ; Riccio, Daniel A ; Schoenfisch, Mark H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a498t-f2432e00a50f76f502de15014a7f13132076960a49357637821381083451e0cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acids</topic><topic>Analytical chemistry</topic><topic>Biosensing Techniques - methods</topic><topic>Chemistry</topic><topic>Exact sciences and technology</topic><topic>Gels - chemistry</topic><topic>General, instrumentation</topic><topic>Hydrogen-Ion Concentration</topic><topic>Kinetics</topic><topic>Manganese - chemistry</topic><topic>Manganese compounds</topic><topic>Neuroprotective Agents - analysis</topic><topic>Nitric oxide</topic><topic>Nitrogen Oxides - analysis</topic><topic>Optics and Photonics</topic><topic>Organometallic Compounds - chemistry</topic><topic>Organosilicon Compounds - chemistry</topic><topic>Porphyrins - chemistry</topic><topic>Sensitivity and Specificity</topic><topic>Sensors</topic><topic>Silicon Dioxide - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dobmeier, Kevin P</creatorcontrib><creatorcontrib>Riccio, Daniel A</creatorcontrib><creatorcontrib>Schoenfisch, Mark H</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dobmeier, Kevin P</au><au>Riccio, Daniel A</au><au>Schoenfisch, Mark H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xerogel Optical Sensor Films for Quantitative Detection of Nitroxyl</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2008-02-15</date><risdate>2008</risdate><volume>80</volume><issue>4</issue><spage>1247</spage><epage>1254</epage><pages>1247-1254</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>Xerogel sensing films synthesized via sol−gel chemistry were used to fabricate optical nitroxyl (HNO) sensors. Selective detection of HNO in solution was achieved by monitoring the rates of manganese(III) meso-tetrakis(4-sulfonatophenyl) porphyrinate (MnIIITPPS) reductive nitrosylation in the anaerobic interior of aminoalkoxysilane-derived xerogel films. Nitroxyl permeability in sensor films deposited in round-bottom 96-well plates was enhanced via incorporation of trimethoxysilyl-terminated poly(amidoamine-organosilicon) dendrimers in the xerogel network. The selectivity of MnIIITPPS for HNO, the overall sensitivity, and the working dynamic range of the resulting sensors were characterized. The HNO-sensing microtiter plates were used to quantify pH-dependent HNO generation by the recently described HNO-donor sodium 1-(isopropylamino)diazene-1-ium-1,2-diolate (IPA/NO), and compare HNO production efficiency between IPA/NO and Angeli's salt, a traditional HNO-donor.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>18197695</pmid><doi>10.1021/ac702024t</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Analytical chemistry Biosensing Techniques - methods Chemistry Exact sciences and technology Gels - chemistry General, instrumentation Hydrogen-Ion Concentration Kinetics Manganese - chemistry Manganese compounds Neuroprotective Agents - analysis Nitric oxide Nitrogen Oxides - analysis Optics and Photonics Organometallic Compounds - chemistry Organosilicon Compounds - chemistry Porphyrins - chemistry Sensitivity and Specificity Sensors Silicon Dioxide - chemistry |
| title | Xerogel Optical Sensor Films for Quantitative Detection of Nitroxyl |
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