Hepatic Cyp2d and Cyp26a1 mRNAs and activities are increased during mouse pregnancy

There is considerable evidence that drug disposition is altered during human pregnancy and based on probe drug studies, CYP2D6 activity increases during human pregnancy. The aim of this study was to determine whether the changes of CYP2D6 activity observed during human pregnancy could be replicated...

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Veröffentlicht in:	Drug metabolism and disposition 2013-02, Vol.41 (2), p.312-319
Hauptverfasser:	Topletz, Ariel R, Le, Huong N, Lee, Nora, Chapman, John D, Kelly, Edward J, Wang, Joanne, Isoherranen, Nina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics Cytochrome P450 Family 2 Dextromethorphan - metabolism Dextrorphan - metabolism Enzyme Induction Female Hydroxylation Liver - enzymology Mice Models, Animal Pregnancy Receptors, Retinoic Acid - biosynthesis Receptors, Retinoic Acid - genetics Response Elements Retinoic Acid 4-Hydroxylase Retinoic Acid Receptor alpha RNA, Messenger - biosynthesis Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy Substrate Specificity Tretinoin - metabolism
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