Transgene-mediated suppression of the RNA interference pathway in Aedes aegypti interferes with gene silencing and enhances Sindbis virus and dengue virus type 2 replication

RNA interference (RNAi) is the major innate antiviral pathway in Aedes aegypti that responds to replicating arboviruses such as dengue virus (DENV) and Sindbis virus (SINV). On the one hand, the mosquito's RNAi machinery is capable of completely eliminating DENV2 from Ae. aegypti. On the other,...

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Veröffentlicht in:	Insect molecular biology 2013-02, Vol.22 (1), p.104-114
Hauptverfasser:	Khoo, C. C. H., Doty, J. B., Heersink, M. S., Olson, K. E., Franz, A. W. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes - genetics Aedes - virology Aedes aegypti Animals Animals, Genetically Modified dengue virus Dengue Virus - pathogenicity Dengue Virus - physiology Female FHV-B2 Gastrointestinal Tract - physiology Gene Expression Gene Silencing mosquito Nodaviridae - genetics Polyubiquitin - genetics Promoter Regions, Genetic RNA Interference RNAi suppression Sindbis virus Sindbis Virus - pathogenicity Sindbis Virus - physiology Transgenes transgenic Virus Replication - genetics ΦC31 recombination
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