Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene

N-Acetyl-S-(1,2-dichlorovinyl)-l-cysteine (NA-DCVC) has been detected in the urine of humans exposed to trichloroethylene and its related sulfoxide, N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine sulfoxide (NA-DCVCS), has been detected as hemoglobin adducts in blood of rats dosed with S-(1,2-dichloroviny...

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Veröffentlicht in:	Toxicology and applied pharmacology 2013-02, Vol.267 (1), p.1-10
Hauptverfasser:	Irving, Roy M., Pinkerton, Marie E., Elfarra, Adnan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACETONITRILE Acetylcysteine - analogs & derivatives Acetylcysteine - metabolism Acetylcysteine - toxicity Adducts ALANINES AMINOTRANSFERASES Animals Biological and medical sciences BLOOD Catalysis Chemical and industrial products toxicology. Toxic occupational diseases CHLORIDES CYSTEINE Cytosol GLUTATHIONE GLUTATHIONE CONJUGATES GSH conjugation HEMOGLOBIN Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - pathology LIVER Male Medical sciences METABOLISM Metabolites N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine sulfoxide Nephrotoxicity NITROGEN Phosphate Proximal tubules RATS Rats, Sprague-Dawley Renal function S-(1,2-dichlorovinyl)-l-cysteine Solvents TOXICITY Toxicology Trichloroethylene Trichloroethylene - chemistry Trichloroethylene - metabolism Trichloroethylene - toxicity TUBULES URINE
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