The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis
Neuroblastoma is a highly heterogeneous tumor accounting for 15 % of all pediatric cancer deaths. Clinical behavior ranges from the spontaneous regression of localized, asymptomatic tumors, as well as metastasized tumors in infants, to rapid progression and resistance to therapy. Genomic amplificati...
Gespeichert in:
| Veröffentlicht in: | Pediatric surgery international 2013-02, Vol.29 (2), p.101-119 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 119 |
|---|---|
| container_issue | 2 |
| container_start_page | 101 |
| container_title | Pediatric surgery international |
| container_volume | 29 |
| creator | Domingo-Fernandez, Raquel Watters, Karen Piskareva, Olga Stallings, Raymond L. Bray, Isabella |
| description | Neuroblastoma is a highly heterogeneous tumor accounting for 15 % of all pediatric cancer deaths. Clinical behavior ranges from the spontaneous regression of localized, asymptomatic tumors, as well as metastasized tumors in infants, to rapid progression and resistance to therapy. Genomic amplification of the MYCN oncogene has been used to predict outcome in neuroblastoma for over 30 years, however, recent methodological advances including miRNA and mRNA profiling, comparative genomic hybridization (array-CGH), and whole-genome sequencing have enabled the detailed analysis of the neuroblastoma genome, leading to the identification of new prognostic markers and better patient stratification. In this review, we will describe the main genetic factors responsible for these diverse clinical phenotypes in neuroblastoma, the chronology of their discovery, and the impact on patient prognosis. |
| doi_str_mv | 10.1007/s00383-012-3239-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3557462</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1492626402</sourcerecordid><originalsourceid>FETCH-LOGICAL-c569t-6b33fe35389abe71cd988bb453b71c27dd9fa4c6606160c91a33d1809cbcb4ca3</originalsourceid><addsrcrecordid>eNp1kU2LFDEQhoMo7rj6A7xIgxcvrZVUdz4ugix-wYKX8RySdPVMlp5kTLoF_709zDqsgqeiqOd9q4qXsZcc3nIA9a4CoMYWuGhRoGnVI7bhHarWaI6P2Qa4Mi1gr6_Ys1rvAECjNE_ZlUChOgV8w7bbPTUlT9TksdlRojmGxqWhoWO8tNNMxc0xp9rE1CRaSvaTq3M-uGaIlVyl5ujmfT4paqzP2ZPRTZVe3Ndr9v3Tx-3Nl_b22-evNx9u29BLM7fSI46EPWrjPCkeBqO1912Pfm2EGgYzui5ICZJLCIY7xIFrMMEH3wWH1-z92fe4-AMNgdJc3GSPJR5c-WWzi_bvSYp7u8s_Lfa96qRYDd7cG5T8Y6E620OsgabJJcpLtbwzQgrZwQl9_Q96l5eS1vcsF0r3WvUCVoqfqVByrYXGyzEc7Ckze87MrpnZU2ZWrZpXD7-4KP6EtALiDNR1lHZUHqz-r-tvz1SjOQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1278587520</pqid></control><display><type>article</type><title>The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Domingo-Fernandez, Raquel ; Watters, Karen ; Piskareva, Olga ; Stallings, Raymond L. ; Bray, Isabella</creator><creatorcontrib>Domingo-Fernandez, Raquel ; Watters, Karen ; Piskareva, Olga ; Stallings, Raymond L. ; Bray, Isabella</creatorcontrib><description>Neuroblastoma is a highly heterogeneous tumor accounting for 15 % of all pediatric cancer deaths. Clinical behavior ranges from the spontaneous regression of localized, asymptomatic tumors, as well as metastasized tumors in infants, to rapid progression and resistance to therapy. Genomic amplification of the MYCN oncogene has been used to predict outcome in neuroblastoma for over 30 years, however, recent methodological advances including miRNA and mRNA profiling, comparative genomic hybridization (array-CGH), and whole-genome sequencing have enabled the detailed analysis of the neuroblastoma genome, leading to the identification of new prognostic markers and better patient stratification. In this review, we will describe the main genetic factors responsible for these diverse clinical phenotypes in neuroblastoma, the chronology of their discovery, and the impact on patient prognosis.</description><identifier>ISSN: 0179-0358</identifier><identifier>EISSN: 1437-9813</identifier><identifier>DOI: 10.1007/s00383-012-3239-7</identifier><identifier>PMID: 23274701</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Cancer ; Child ; Chromosome Deletion ; Chromosome Mapping - methods ; Epigenomics - methods ; Humans ; Medicine ; Medicine & Public Health ; Neuroblastoma - genetics ; Pediatric Surgery ; Pediatrics ; Review Article ; Surgery</subject><ispartof>Pediatric surgery international, 2013-02, Vol.29 (2), p.101-119</ispartof><rights>Springer-Verlag Berlin Heidelberg 2012</rights><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>Springer-Verlag Berlin Heidelberg 2012 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-6b33fe35389abe71cd988bb453b71c27dd9fa4c6606160c91a33d1809cbcb4ca3</citedby><cites>FETCH-LOGICAL-c569t-6b33fe35389abe71cd988bb453b71c27dd9fa4c6606160c91a33d1809cbcb4ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00383-012-3239-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00383-012-3239-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23274701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Domingo-Fernandez, Raquel</creatorcontrib><creatorcontrib>Watters, Karen</creatorcontrib><creatorcontrib>Piskareva, Olga</creatorcontrib><creatorcontrib>Stallings, Raymond L.</creatorcontrib><creatorcontrib>Bray, Isabella</creatorcontrib><title>The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis</title><title>Pediatric surgery international</title><addtitle>Pediatr Surg Int</addtitle><addtitle>Pediatr Surg Int</addtitle><description>Neuroblastoma is a highly heterogeneous tumor accounting for 15 % of all pediatric cancer deaths. Clinical behavior ranges from the spontaneous regression of localized, asymptomatic tumors, as well as metastasized tumors in infants, to rapid progression and resistance to therapy. Genomic amplification of the MYCN oncogene has been used to predict outcome in neuroblastoma for over 30 years, however, recent methodological advances including miRNA and mRNA profiling, comparative genomic hybridization (array-CGH), and whole-genome sequencing have enabled the detailed analysis of the neuroblastoma genome, leading to the identification of new prognostic markers and better patient stratification. In this review, we will describe the main genetic factors responsible for these diverse clinical phenotypes in neuroblastoma, the chronology of their discovery, and the impact on patient prognosis.</description><subject>Cancer</subject><subject>Child</subject><subject>Chromosome Deletion</subject><subject>Chromosome Mapping - methods</subject><subject>Epigenomics - methods</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroblastoma - genetics</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Review Article</subject><subject>Surgery</subject><issn>0179-0358</issn><issn>1437-9813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU2LFDEQhoMo7rj6A7xIgxcvrZVUdz4ugix-wYKX8RySdPVMlp5kTLoF_709zDqsgqeiqOd9q4qXsZcc3nIA9a4CoMYWuGhRoGnVI7bhHarWaI6P2Qa4Mi1gr6_Ys1rvAECjNE_ZlUChOgV8w7bbPTUlT9TksdlRojmGxqWhoWO8tNNMxc0xp9rE1CRaSvaTq3M-uGaIlVyl5ujmfT4paqzP2ZPRTZVe3Ndr9v3Tx-3Nl_b22-evNx9u29BLM7fSI46EPWrjPCkeBqO1912Pfm2EGgYzui5ICZJLCIY7xIFrMMEH3wWH1-z92fe4-AMNgdJc3GSPJR5c-WWzi_bvSYp7u8s_Lfa96qRYDd7cG5T8Y6E620OsgabJJcpLtbwzQgrZwQl9_Q96l5eS1vcsF0r3WvUCVoqfqVByrYXGyzEc7Ckze87MrpnZU2ZWrZpXD7-4KP6EtALiDNR1lHZUHqz-r-tvz1SjOQ</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Domingo-Fernandez, Raquel</creator><creator>Watters, Karen</creator><creator>Piskareva, Olga</creator><creator>Stallings, Raymond L.</creator><creator>Bray, Isabella</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20130201</creationdate><title>The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis</title><author>Domingo-Fernandez, Raquel ; Watters, Karen ; Piskareva, Olga ; Stallings, Raymond L. ; Bray, Isabella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-6b33fe35389abe71cd988bb453b71c27dd9fa4c6606160c91a33d1809cbcb4ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Cancer</topic><topic>Child</topic><topic>Chromosome Deletion</topic><topic>Chromosome Mapping - methods</topic><topic>Epigenomics - methods</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroblastoma - genetics</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Review Article</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Domingo-Fernandez, Raquel</creatorcontrib><creatorcontrib>Watters, Karen</creatorcontrib><creatorcontrib>Piskareva, Olga</creatorcontrib><creatorcontrib>Stallings, Raymond L.</creatorcontrib><creatorcontrib>Bray, Isabella</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric surgery international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Domingo-Fernandez, Raquel</au><au>Watters, Karen</au><au>Piskareva, Olga</au><au>Stallings, Raymond L.</au><au>Bray, Isabella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis</atitle><jtitle>Pediatric surgery international</jtitle><stitle>Pediatr Surg Int</stitle><addtitle>Pediatr Surg Int</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>29</volume><issue>2</issue><spage>101</spage><epage>119</epage><pages>101-119</pages><issn>0179-0358</issn><eissn>1437-9813</eissn><abstract>Neuroblastoma is a highly heterogeneous tumor accounting for 15 % of all pediatric cancer deaths. Clinical behavior ranges from the spontaneous regression of localized, asymptomatic tumors, as well as metastasized tumors in infants, to rapid progression and resistance to therapy. Genomic amplification of the MYCN oncogene has been used to predict outcome in neuroblastoma for over 30 years, however, recent methodological advances including miRNA and mRNA profiling, comparative genomic hybridization (array-CGH), and whole-genome sequencing have enabled the detailed analysis of the neuroblastoma genome, leading to the identification of new prognostic markers and better patient stratification. In this review, we will describe the main genetic factors responsible for these diverse clinical phenotypes in neuroblastoma, the chronology of their discovery, and the impact on patient prognosis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23274701</pmid><doi>10.1007/s00383-012-3239-7</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0179-0358 |
| ispartof | Pediatric surgery international, 2013-02, Vol.29 (2), p.101-119 |
| issn | 0179-0358 1437-9813 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3557462 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Cancer Child Chromosome Deletion Chromosome Mapping - methods Epigenomics - methods Humans Medicine Medicine & Public Health Neuroblastoma - genetics Pediatric Surgery Pediatrics Review Article Surgery |
| title | The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T19%3A51%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20genetic%20and%20epigenetic%20alterations%20in%20neuroblastoma%20disease%20pathogenesis&rft.jtitle=Pediatric%20surgery%20international&rft.au=Domingo-Fernandez,%20Raquel&rft.date=2013-02-01&rft.volume=29&rft.issue=2&rft.spage=101&rft.epage=119&rft.pages=101-119&rft.issn=0179-0358&rft.eissn=1437-9813&rft_id=info:doi/10.1007/s00383-012-3239-7&rft_dat=%3Cproquest_pubme%3E1492626402%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1278587520&rft_id=info:pmid/23274701&rfr_iscdi=true |