Can Bone Tissue Engineering Contribute to Therapy Concepts after Resection of Musculoskeletal Sarcoma?
Resection of musculoskeletal sarcoma can result in large bone defects where regeneration is needed in a quantity far beyond the normal potential of self-healing. In many cases, these defects exhibit a limited intrinsic regenerative potential due to an adjuvant therapeutic regimen, seroma, or infecti...
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| Veröffentlicht in: | Complexity (New York, N.Y.) N.Y.), 2013, Vol.2013 (2013), p.18-27 |
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| creator | Hutmacher, Dietmar Werner Rudert, Maximilian van Griensven, Martijn von Eisenhart-Rothe, Ruediger Prodinger, Peter Michael Holzapfel, Nina Pauline Melchels, Ferry Petrus Wilhelmus Chhaya, Mohit Prashant Holzapfel, Boris Michael Schantz, Jan-Thorsten |
| description | Resection of musculoskeletal sarcoma can result in large bone defects where regeneration is needed in a quantity far beyond the normal potential of self-healing. In many cases, these defects exhibit a limited intrinsic regenerative potential due to an adjuvant therapeutic regimen, seroma, or infection. Therefore, reconstruction of these defects is still one of the most demanding procedures in orthopaedic surgery. The constraints of common treatment strategies have triggered a need for new therapeutic concepts to design and engineer unparalleled structural and functioning bone grafts. To satisfy the need for long-term repair and good clinical outcome, a paradigm shift is needed from methods to replace tissues with inert medical devices to more biological approaches that focus on the repair and reconstruction of tissue structure and function. It is within this context that the field of bone tissue engineering can offer solutions to be implemented into surgical therapy concepts after resection of bone and soft tissue sarcoma. In this paper we will discuss the implementation of tissue engineering concepts into the clinical field of orthopaedic oncology. |
| doi_str_mv | 10.1155/2013/153640 |
| format | Article |
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In many cases, these defects exhibit a limited intrinsic regenerative potential due to an adjuvant therapeutic regimen, seroma, or infection. Therefore, reconstruction of these defects is still one of the most demanding procedures in orthopaedic surgery. The constraints of common treatment strategies have triggered a need for new therapeutic concepts to design and engineer unparalleled structural and functioning bone grafts. To satisfy the need for long-term repair and good clinical outcome, a paradigm shift is needed from methods to replace tissues with inert medical devices to more biological approaches that focus on the repair and reconstruction of tissue structure and function. It is within this context that the field of bone tissue engineering can offer solutions to be implemented into surgical therapy concepts after resection of bone and soft tissue sarcoma. In this paper we will discuss the implementation of tissue engineering concepts into the clinical field of orthopaedic oncology.</description><identifier>ISSN: 1357-714X</identifier><identifier>ISSN: 1076-2787</identifier><identifier>EISSN: 1099-0526</identifier><identifier>EISSN: 1369-1643</identifier><identifier>DOI: 10.1155/2013/153640</identifier><identifier>PMID: 23509421</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Care and treatment ; Health aspects ; Orthopedic surgery ; Review ; Sarcoma ; Tissue engineering</subject><ispartof>Complexity (New York, N.Y.), 2013, Vol.2013 (2013), p.18-27</ispartof><rights>Copyright © 2013 Boris Michael Holzapfel et al.</rights><rights>COPYRIGHT 2013 John Wiley & Sons, Inc.</rights><rights>Copyright © 2013 Boris Michael Holzapfel et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a5190-5f1bc7f47fcb2fea5e7872b1d6e44b438921f3001cdd43207ceee867009d97643</citedby><cites>FETCH-LOGICAL-a5190-5f1bc7f47fcb2fea5e7872b1d6e44b438921f3001cdd43207ceee867009d97643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556880/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556880/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23509421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rechl, Hans</contributor><creatorcontrib>Hutmacher, Dietmar Werner</creatorcontrib><creatorcontrib>Rudert, Maximilian</creatorcontrib><creatorcontrib>van Griensven, Martijn</creatorcontrib><creatorcontrib>von Eisenhart-Rothe, Ruediger</creatorcontrib><creatorcontrib>Prodinger, Peter Michael</creatorcontrib><creatorcontrib>Holzapfel, Nina Pauline</creatorcontrib><creatorcontrib>Melchels, Ferry Petrus Wilhelmus</creatorcontrib><creatorcontrib>Chhaya, Mohit Prashant</creatorcontrib><creatorcontrib>Holzapfel, Boris Michael</creatorcontrib><creatorcontrib>Schantz, Jan-Thorsten</creatorcontrib><title>Can Bone Tissue Engineering Contribute to Therapy Concepts after Resection of Musculoskeletal Sarcoma?</title><title>Complexity (New York, N.Y.)</title><addtitle>Sarcoma</addtitle><description>Resection of musculoskeletal sarcoma can result in large bone defects where regeneration is needed in a quantity far beyond the normal potential of self-healing. 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In this paper we will discuss the implementation of tissue engineering concepts into the clinical field of orthopaedic oncology.</description><subject>Care and treatment</subject><subject>Health aspects</subject><subject>Orthopedic surgery</subject><subject>Review</subject><subject>Sarcoma</subject><subject>Tissue engineering</subject><issn>1357-714X</issn><issn>1076-2787</issn><issn>1099-0526</issn><issn>1369-1643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><recordid>eNqNkt9rFDEQxxdRbK0--S4LgohybSY_NrsvSj3qLyqKnuBbyGYnd2n3kjPZVfrfm2Vr6YEPkodJJp_5wsx8i-IxkGMAIU4oAXYCglWc3CkOgTTNggha3c13JuRCAv9xUDxI6YIQwjnj94sDygRpOIXDwi61L98Ej-XKpTRieebXziNG59flMvghunYcsBxCudpg1LurKWtwN6RS2wFj-RUTmsEFXwZbfhqTGfuQLrHHQfflNx1N2OrXD4t7VvcJH13Ho-L727PV8v3i_PO7D8vT84UW0JCFsNAaabm0pqUWtUBZS9pCVyHnLWd1Q8EyQsB0HWeUSIOIdSUJabpGVpwdFa9m3d3YbrEzmBvQvdpFt9XxSgXt1P6Pdxu1Dr8UE6Kqa5IFnl8LxPBzxDSorUsG-157DGNSwKAmjRSSZfTpjK51j8p5G7KimXB1ymST18EZZOr4H1Q-HW6dyYO3Luf3Cp7dKtig7odNCv04jTjtgy9n0MSQUkR70yYQNTlDTc5QszMy_eT2ZG7Yv1bIwIsZ2Djf6d_u_9QwI2j1LRiAM5mBjzOgXXSDUxdhjD5vXn3JMgIopYTMkkCnIAmlkA3K9h9QKyrZH86D3LQ</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Hutmacher, Dietmar Werner</creator><creator>Rudert, Maximilian</creator><creator>van Griensven, Martijn</creator><creator>von Eisenhart-Rothe, Ruediger</creator><creator>Prodinger, Peter Michael</creator><creator>Holzapfel, Nina Pauline</creator><creator>Melchels, Ferry Petrus Wilhelmus</creator><creator>Chhaya, Mohit Prashant</creator><creator>Holzapfel, Boris Michael</creator><creator>Schantz, Jan-Thorsten</creator><general>Hindawi Limiteds</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><scope>188</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>AHMDM</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2013</creationdate><title>Can Bone Tissue Engineering Contribute to Therapy Concepts after Resection of Musculoskeletal Sarcoma?</title><author>Hutmacher, Dietmar Werner ; 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| ispartof | Complexity (New York, N.Y.), 2013, Vol.2013 (2013), p.18-27 |
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| source | Wiley-Blackwell Open Access Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Care and treatment Health aspects Orthopedic surgery Review Sarcoma Tissue engineering |
| title | Can Bone Tissue Engineering Contribute to Therapy Concepts after Resection of Musculoskeletal Sarcoma? |
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