Neuroinflammation and neurodegeneration in overnutrition-induced diseases
Overnutrition-induced diseases such as obesity and type 2 diabetes (T2D) involve neural dysregulation of metabolic physiology. Recently, interdisciplinary research in neuroscience and immunology has linked overnutrition to a non-classical onset of inflammation in the brain, particularly in the hypot...
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| Veröffentlicht in: | Trends in endocrinology and metabolism 2013-01, Vol.24 (1), p.40-47 |
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| description | Overnutrition-induced diseases such as obesity and type 2 diabetes (T2D) involve neural dysregulation of metabolic physiology. Recently, interdisciplinary research in neuroscience and immunology has linked overnutrition to a non-classical onset of inflammation in the brain, particularly in the hypothalamus. This neuroinflammation impairs central regulatory pathways of energy balance and nutrient metabolism, and leads to obesity, diabetes, and cardiovascular complications. This review describes recent findings on the roles of overnutrition-induced hypothalamic inflammation in neurodegeneration and defective adult neurogenesis, as well as in impaired neural stem cell regeneration, and their relevance to obesity and related diseases. In addition, commonalities in terms of neuroinflammation between neurodegenerative diseases and overnutrition-induced metabolic diseases are discussed. Targeting neuroinflammation and neurodegeneration will provide promising approaches for treating obesity and other overnutrition-related diseases. |
| doi_str_mv | 10.1016/j.tem.2012.11.003 |
| format | Article |
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Targeting neuroinflammation and neurodegeneration will provide promising approaches for treating obesity and other overnutrition-related diseases.</description><identifier>ISSN: 1043-2760</identifier><identifier>EISSN: 1879-3061</identifier><identifier>DOI: 10.1016/j.tem.2012.11.003</identifier><identifier>PMID: 23265946</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animals ; brain ; diabetes ; Endocrinology & Metabolism ; Humans ; hypothalamus ; Hypothalamus - cytology ; Hypothalamus - metabolism ; inflammation ; Inflammation - etiology ; Inflammation - metabolism ; neural stem cells ; Neural Stem Cells - metabolism ; neurodegeneration ; Neurodegenerative Diseases - etiology ; Neurodegenerative Diseases - metabolism ; NF-κB ; obesity ; Obesity - etiology ; Obesity - metabolism ; Overnutrition - complications</subject><ispartof>Trends in endocrinology and metabolism, 2013-01, Vol.24 (1), p.40-47</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. 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Targeting neuroinflammation and neurodegeneration will provide promising approaches for treating obesity and other overnutrition-related diseases.</description><subject>Animals</subject><subject>brain</subject><subject>diabetes</subject><subject>Endocrinology & Metabolism</subject><subject>Humans</subject><subject>hypothalamus</subject><subject>Hypothalamus - cytology</subject><subject>Hypothalamus - metabolism</subject><subject>inflammation</subject><subject>Inflammation - etiology</subject><subject>Inflammation - metabolism</subject><subject>neural stem cells</subject><subject>Neural Stem Cells - metabolism</subject><subject>neurodegeneration</subject><subject>Neurodegenerative Diseases - etiology</subject><subject>Neurodegenerative Diseases - metabolism</subject><subject>NF-κB</subject><subject>obesity</subject><subject>Obesity - etiology</subject><subject>Obesity - metabolism</subject><subject>Overnutrition - complications</subject><issn>1043-2760</issn><issn>1879-3061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl9rFDEUxYMotq5-AF9kH32ZNTf_ZgahIEVtoeiD-nzJJndr1pmkJjML_fZm2FqqDwqBhJNzD8n9XcZeAt8AB_Nmv5lo3AgOYgOw4Vw-YqfQtX0juYHH9cyVbERr-Al7Vsqec1Ad6KfsREhhdK_MKbv8RHNOIe4GO452CimubfTruKierilSPqohrtOBcpynHBahCdHPjvzah0K2UHnOnuzsUOjF3b5i3z68_3p-0Vx9_nh5_u6qcVr2UyOUsba1nSalt8a2xhtJCiTnQjjTWcU9l63RWreiN853ypE1xnrtt0p4J1fs7Jh7M29H8o7ilO2ANzmMNt9isgH_vInhO16nA0qtjepMDXh9F5DTz5nKhGMojobBRkpzQVDQS6NF1__fKlrZ8k7WtWJwtLqcSsm0u38RcFxo4R4rLVxoIQBWWrXm1cOv3Ff8xlMNb48Gqg09BMpYXKBY2x4yuQl9Cv-MP_ur2g0hBmeHH3RLZZ_mHCspBCwCOX5ZxmWZFhAVBpdC_gJ5brt5</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Cai, Dongsheng</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Neuroinflammation and neurodegeneration in overnutrition-induced diseases</title><author>Cai, Dongsheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-246aa7a85e45b6a76d63e4130022c68a40d03765557296cd84cea66ad5db42dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>brain</topic><topic>diabetes</topic><topic>Endocrinology & Metabolism</topic><topic>Humans</topic><topic>hypothalamus</topic><topic>Hypothalamus - cytology</topic><topic>Hypothalamus - metabolism</topic><topic>inflammation</topic><topic>Inflammation - etiology</topic><topic>Inflammation - metabolism</topic><topic>neural stem cells</topic><topic>Neural Stem Cells - metabolism</topic><topic>neurodegeneration</topic><topic>Neurodegenerative Diseases - etiology</topic><topic>Neurodegenerative Diseases - metabolism</topic><topic>NF-κB</topic><topic>obesity</topic><topic>Obesity - etiology</topic><topic>Obesity - metabolism</topic><topic>Overnutrition - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Dongsheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Trends in endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Dongsheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroinflammation and neurodegeneration in overnutrition-induced diseases</atitle><jtitle>Trends in endocrinology and metabolism</jtitle><addtitle>Trends Endocrinol Metab</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>24</volume><issue>1</issue><spage>40</spage><epage>47</epage><pages>40-47</pages><issn>1043-2760</issn><eissn>1879-3061</eissn><abstract>Overnutrition-induced diseases such as obesity and type 2 diabetes (T2D) involve neural dysregulation of metabolic physiology. 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| fulltext | fulltext |
| identifier | ISSN: 1043-2760 |
| ispartof | Trends in endocrinology and metabolism, 2013-01, Vol.24 (1), p.40-47 |
| issn | 1043-2760 1879-3061 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals brain diabetes Endocrinology & Metabolism Humans hypothalamus Hypothalamus - cytology Hypothalamus - metabolism inflammation Inflammation - etiology Inflammation - metabolism neural stem cells Neural Stem Cells - metabolism neurodegeneration Neurodegenerative Diseases - etiology Neurodegenerative Diseases - metabolism NF-κB obesity Obesity - etiology Obesity - metabolism Overnutrition - complications |
| title | Neuroinflammation and neurodegeneration in overnutrition-induced diseases |
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