Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis in Pancreatic Cancer: A Prospective Pilot Study of Safety Using 10 mL versus 20 mL Alcohol
Background. The dose of alcohol used in EUS-CPN is not standardized. The objective was to compare the safety of 20 mL alcohol versus 10 mL alcohol during EUS-CPN for patients with pancreatic cancer-related pain. Methods. 20 patients were selected to receive 10 mL or 20 mL of alcohol during EUS-CPN....
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| Veröffentlicht in: | Diagnostic and Therapeutic Endoscopy 2013, Vol.2013 (2013), p.61-66 |
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| container_title | Diagnostic and Therapeutic Endoscopy |
| container_volume | 2013 |
| creator | LeBlanc, Julia K. Rawl, Susan M. Juan, Michelle Johnson, Cynthia Kroenke, Kurt McHenry, Lee Sherman, Stuart McGreevy, Kathy al-Haddad, Mohammad DeWitt, John M. |
| description | Background. The dose of alcohol used in EUS-CPN is not standardized. The objective was to compare the safety of 20 mL alcohol versus 10 mL alcohol during EUS-CPN for patients with pancreatic cancer-related pain. Methods. 20 patients were selected to receive 10 mL or 20 mL of alcohol during EUS-CPN. Followup was done at baseline, 24 hours, and weekly. Health-related quality of life (HRQoL) was assessed at baseline, week 2, week 4, and every 4 weeks thereafter until pain returned. Results. There were no major complications in both groups. Minor self-limited adverse effects were seen in 6 (30%) subjects and included lightheadedness in 1 (5%), transient diarrhea in 2 (10%), and transient nausea and vomiting in 3. Pain relief was similar in both groups: 80% in the 10 mL group and 100% in the 20 mL group (P=0.21). The mean (± SD) duration of pain relief in the 10 mL and 20 mL groups was 7.9±10.8 and 8.4±9.2 weeks, respectively. 30% of patients in each group had complete pain relief. Conclusions. EUS-CPN using 20 mL of alcohol is safe. Similar clinical outcomes were seen in both groups. Further investigations to confirm these findings are warranted. |
| doi_str_mv | 10.1155/2013/327036 |
| format | Article |
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The dose of alcohol used in EUS-CPN is not standardized. The objective was to compare the safety of 20 mL alcohol versus 10 mL alcohol during EUS-CPN for patients with pancreatic cancer-related pain. Methods. 20 patients were selected to receive 10 mL or 20 mL of alcohol during EUS-CPN. Followup was done at baseline, 24 hours, and weekly. Health-related quality of life (HRQoL) was assessed at baseline, week 2, week 4, and every 4 weeks thereafter until pain returned. Results. There were no major complications in both groups. Minor self-limited adverse effects were seen in 6 (30%) subjects and included lightheadedness in 1 (5%), transient diarrhea in 2 (10%), and transient nausea and vomiting in 3. Pain relief was similar in both groups: 80% in the 10 mL group and 100% in the 20 mL group (P=0.21). The mean (± SD) duration of pain relief in the 10 mL and 20 mL groups was 7.9±10.8 and 8.4±9.2 weeks, respectively. 30% of patients in each group had complete pain relief. Conclusions. EUS-CPN using 20 mL of alcohol is safe. Similar clinical outcomes were seen in both groups. Further investigations to confirm these findings are warranted.</description><identifier>ISSN: 1070-3608</identifier><identifier>EISSN: 1029-0516</identifier><identifier>DOI: 10.1155/2013/327036</identifier><identifier>PMID: 23365492</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Clinical Study ; Diarrhea</subject><ispartof>Diagnostic and Therapeutic Endoscopy, 2013, Vol.2013 (2013), p.61-66</ispartof><rights>Copyright © 2013 Julia K. LeBlanc et al.</rights><rights>Copyright © 2013 Julia K. LeBlanc et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a5196-93c9b217d8bbdeee81440cf923bfee6bb639c8d6b382ca6dd089e47657d2f0a13</citedby><cites>FETCH-LOGICAL-a5196-93c9b217d8bbdeee81440cf923bfee6bb639c8d6b382ca6dd089e47657d2f0a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556397/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556397/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23365492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wilcox, Charles Melbern</contributor><creatorcontrib>LeBlanc, Julia K.</creatorcontrib><creatorcontrib>Rawl, Susan M.</creatorcontrib><creatorcontrib>Juan, Michelle</creatorcontrib><creatorcontrib>Johnson, Cynthia</creatorcontrib><creatorcontrib>Kroenke, Kurt</creatorcontrib><creatorcontrib>McHenry, Lee</creatorcontrib><creatorcontrib>Sherman, Stuart</creatorcontrib><creatorcontrib>McGreevy, Kathy</creatorcontrib><creatorcontrib>al-Haddad, Mohammad</creatorcontrib><creatorcontrib>DeWitt, John M.</creatorcontrib><title>Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis in Pancreatic Cancer: A Prospective Pilot Study of Safety Using 10 mL versus 20 mL Alcohol</title><title>Diagnostic and Therapeutic Endoscopy</title><addtitle>Diagn Ther Endosc</addtitle><description>Background. The dose of alcohol used in EUS-CPN is not standardized. The objective was to compare the safety of 20 mL alcohol versus 10 mL alcohol during EUS-CPN for patients with pancreatic cancer-related pain. Methods. 20 patients were selected to receive 10 mL or 20 mL of alcohol during EUS-CPN. Followup was done at baseline, 24 hours, and weekly. Health-related quality of life (HRQoL) was assessed at baseline, week 2, week 4, and every 4 weeks thereafter until pain returned. Results. There were no major complications in both groups. Minor self-limited adverse effects were seen in 6 (30%) subjects and included lightheadedness in 1 (5%), transient diarrhea in 2 (10%), and transient nausea and vomiting in 3. Pain relief was similar in both groups: 80% in the 10 mL group and 100% in the 20 mL group (P=0.21). The mean (± SD) duration of pain relief in the 10 mL and 20 mL groups was 7.9±10.8 and 8.4±9.2 weeks, respectively. 30% of patients in each group had complete pain relief. Conclusions. EUS-CPN using 20 mL of alcohol is safe. Similar clinical outcomes were seen in both groups. Further investigations to confirm these findings are warranted.</description><subject>Clinical Study</subject><subject>Diarrhea</subject><issn>1070-3608</issn><issn>1029-0516</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><recordid>eNqNks1v0zAYhyMEYmNw4gzyEYHC_JE4MQekqhoDVEGl0bPl2G9WT65d7KTQ_4I_GXcZFTvByR_v40d-_XNRPCf4LSF1fU4xYeeMNpjxB8UpwVSUuCb84WHe4JJx3J4UT1K6wRgzTMjj4oQyxutK0NPi14U3IemwtRqt3BBVCqM35eVoDRg0B2eVRksHP8eEvsAYg9snm5D1aKm8jqCGfHCepxDfoRlaxpC2oAe7A7S0LgzoahjNHoUeXakehj1aJeuvEcFos0A7iCl76e1i5nRYB_e0eNQrl-DZ3XhWrD5cfJt_LBdfLz_NZ4tS1UTwUjAtOkoa03adAYCWVBXWvaCs6wF413EmdGt4x1qqFTcGtwKqhteNoT1WhJ0V7yfvduw2YDT43LyT22g3Ku5lUFber3i7ltdhJ1ldZ3eTBa_uBDF8HyENcmOTBueUhzAmSZgQAleY_wdKW9YwTFua0TcTqvNLpgj98UYEy0Pc8hC3nOLO9Mu_mziyf_LNwOsJWFtv1A_7D9uLCYaMQK-OcMVZ01a5_nmqKxvtYOVNGKPPGcllttSEEp4_2K2R0MOQpVjkrer-ghPJOfsNaLLQqg</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>LeBlanc, Julia K.</creator><creator>Rawl, Susan M.</creator><creator>Juan, Michelle</creator><creator>Johnson, Cynthia</creator><creator>Kroenke, Kurt</creator><creator>McHenry, Lee</creator><creator>Sherman, Stuart</creator><creator>McGreevy, Kathy</creator><creator>al-Haddad, Mohammad</creator><creator>DeWitt, John M.</creator><general>Hindawi Limiteds</general><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><scope>188</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>2013</creationdate><title>Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis in Pancreatic Cancer: A Prospective Pilot Study of Safety Using 10 mL versus 20 mL Alcohol</title><author>LeBlanc, Julia K. ; Rawl, Susan M. ; Juan, Michelle ; Johnson, Cynthia ; Kroenke, Kurt ; McHenry, Lee ; Sherman, Stuart ; McGreevy, Kathy ; al-Haddad, Mohammad ; DeWitt, John M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a5196-93c9b217d8bbdeee81440cf923bfee6bb639c8d6b382ca6dd089e47657d2f0a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Clinical Study</topic><topic>Diarrhea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LeBlanc, Julia K.</creatorcontrib><creatorcontrib>Rawl, Susan M.</creatorcontrib><creatorcontrib>Juan, Michelle</creatorcontrib><creatorcontrib>Johnson, Cynthia</creatorcontrib><creatorcontrib>Kroenke, Kurt</creatorcontrib><creatorcontrib>McHenry, Lee</creatorcontrib><creatorcontrib>Sherman, Stuart</creatorcontrib><creatorcontrib>McGreevy, Kathy</creatorcontrib><creatorcontrib>al-Haddad, Mohammad</creatorcontrib><creatorcontrib>DeWitt, John M.</creatorcontrib><collection>Airiti Library</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diagnostic and Therapeutic Endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LeBlanc, Julia K.</au><au>Rawl, Susan M.</au><au>Juan, Michelle</au><au>Johnson, Cynthia</au><au>Kroenke, Kurt</au><au>McHenry, Lee</au><au>Sherman, Stuart</au><au>McGreevy, Kathy</au><au>al-Haddad, Mohammad</au><au>DeWitt, John M.</au><au>Wilcox, Charles Melbern</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis in Pancreatic Cancer: A Prospective Pilot Study of Safety Using 10 mL versus 20 mL Alcohol</atitle><jtitle>Diagnostic and Therapeutic Endoscopy</jtitle><addtitle>Diagn Ther Endosc</addtitle><date>2013</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>61</spage><epage>66</epage><pages>61-66</pages><issn>1070-3608</issn><eissn>1029-0516</eissn><abstract>Background. The dose of alcohol used in EUS-CPN is not standardized. The objective was to compare the safety of 20 mL alcohol versus 10 mL alcohol during EUS-CPN for patients with pancreatic cancer-related pain. Methods. 20 patients were selected to receive 10 mL or 20 mL of alcohol during EUS-CPN. Followup was done at baseline, 24 hours, and weekly. Health-related quality of life (HRQoL) was assessed at baseline, week 2, week 4, and every 4 weeks thereafter until pain returned. Results. There were no major complications in both groups. Minor self-limited adverse effects were seen in 6 (30%) subjects and included lightheadedness in 1 (5%), transient diarrhea in 2 (10%), and transient nausea and vomiting in 3. Pain relief was similar in both groups: 80% in the 10 mL group and 100% in the 20 mL group (P=0.21). The mean (± SD) duration of pain relief in the 10 mL and 20 mL groups was 7.9±10.8 and 8.4±9.2 weeks, respectively. 30% of patients in each group had complete pain relief. Conclusions. EUS-CPN using 20 mL of alcohol is safe. Similar clinical outcomes were seen in both groups. Further investigations to confirm these findings are warranted.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Limiteds</pub><pmid>23365492</pmid><doi>10.1155/2013/327036</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Clinical Study Diarrhea |
| title | Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis in Pancreatic Cancer: A Prospective Pilot Study of Safety Using 10 mL versus 20 mL Alcohol |
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