PWZ-029, an inverse agonist selective for α5 GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats

► PWZ-029 is an α5 GABAA selective inverse agonist. ► We tested PWZ-029, on its own and with scopolamine, in two memory paradigms. ► It improved object recognition in the novel object recognition test. ► PWZ-029 was ineffective in the Morris water maze test. ► Testing of putative procognitive compou...

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Veröffentlicht in:	Behavioural brain research 2013-03, Vol.241, p.206-213
Hauptverfasser:	Milić, Marija, Timić, Tamara, Joksimović, Srđan, Biawat, Poonam, Rallapalli, Sundari, Divljaković, Jovana, Radulović, Tamara, Cook, James M., Savić, Miroslav M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavioral psychophysiology Benzodiazepines - pharmacology Biological and medical sciences Drug Inverse Agonism Fundamental and applied biological sciences. Psychology GABA GABA-A Receptor Agonists - pharmacology Inverse agonist Male Maze Learning - drug effects Memory Muscarinic Antagonists - pharmacology Object recognition Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Reaction Time - drug effects Receptors, GABA-A - metabolism Recognition (Psychology) - drug effects Scopolamine Hydrobromide - pharmacology Water maze
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