Functional diversification of ROK-family transcriptional regulators of sugar catabolism in the Thermotogae phylum

Large and functionally heterogeneous families of transcription factors have complex evolutionary histories. What shapes specificities toward effectors and DNA sites in paralogous regulators is a fundamental question in biology. Bacteria from the deep-branching lineage Thermotogae possess multiple pa...

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Veröffentlicht in:	Nucleic acids research 2013-01, Vol.41 (2), p.790-803
Hauptverfasser:	Kazanov, Marat D, Li, Xiaoqing, Gelfand, Mikhail S, Osterman, Andrei L, Rodionov, Dmitry A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Bacteria - metabolism Bacterial Proteins - chemistry Bacterial Proteins - classification Bacterial Proteins - metabolism BASIC BIOLOGICAL SCIENCES Binding Sites Carbohydrate Metabolism chromatin Disaccharides DNA DNA, Bacterial - chemistry DNA, Bacterial - metabolism epigenetics Evolution Gene regulation Gene Regulation, Chromatin and Epigenetics Genome, Bacterial Genomes genomics Nucleotide Motifs Open reading frames Phylogeny Regulon Repressors Sugar Thermotoga maritima Thermotoga maritima - genetics Transcription factors Transcription Factors - chemistry Transcription Factors - classification Transcription Factors - metabolism
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