Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells

Polycomb-mediated gene repression is essential for embryonic development, yet its precise role in lineage-specific programming is poorly understood. Here we inactivated Ring1b, encoding a polycomb-repressive complex 1 subunit, in pancreatic multipotent progenitors (Ring1b(progKO)). This caused trans...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genes & development 2013-01, Vol.27 (1), p.52-63
Hauptverfasser:	van Arensbergen, Joris, García-Hurtado, Javier, Maestro, Miguel Angel, Correa-Tapia, Miguel, Rutter, Guy A, Vidal, Miguel, Ferrer, Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cells, Cultured DNA Methylation Embryo, Mammalian Epigenesis, Genetic Gene Expression Regulation, Developmental Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism Male Mice Neurons - metabolism Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Research Paper Stem Cells - cytology Stem Cells - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!