A modified double injection model of cisterna magna for the study of delayed cerebral vasospasm following subarachnoid hemorrhage in rats
Delayed cerebral vasospasm following subarachnoid hemorrhage (SAH) is a serious medical complication, characterized by constriction of cerebral arteries leading to varying degrees of cerebral ischemia. Numerous clinical and experimental studies have been performed in the last decades; however, the p...
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| Veröffentlicht in: | Experimental & translational stroke medicine 2012-11, Vol.4 (1), p.23-23, Article 23 |
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| creator | Raslan, Furat Albert-Weißenberger, Christiane Westermaier, Thomas Saker, Saker Kleinschnitz, Christoph Lee, Jin-Yul |
| description | Delayed cerebral vasospasm following subarachnoid hemorrhage (SAH) is a serious medical complication, characterized by constriction of cerebral arteries leading to varying degrees of cerebral ischemia. Numerous clinical and experimental studies have been performed in the last decades; however, the pathophysiologic mechanism of cerebral vasospasm after SAH still remains unclear. Among a variety of experimental SAH models, the double hemorrhage rat model involving direct injection of autologous arterial blood into the cisterna magna has been used most frequently for the study of delayed cerebral vasospasm following SAH in last years. Despite the simplicity of the technique, the second blood injection into the cisterna magna may result in brainstem injury leading to high mortality. Therefore, a modified double hemorrhage model of cisterna magna has been developed in rat recently. We describe here step by step the surgical technique to induce double SAH and compare the degree of vasospasm with other cisterna magna rat models using histological assessment of the diameter and cross-sectional area of the basilar artery. |
| doi_str_mv | 10.1186/2040-7378-4-23 |
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Numerous clinical and experimental studies have been performed in the last decades; however, the pathophysiologic mechanism of cerebral vasospasm after SAH still remains unclear. Among a variety of experimental SAH models, the double hemorrhage rat model involving direct injection of autologous arterial blood into the cisterna magna has been used most frequently for the study of delayed cerebral vasospasm following SAH in last years. Despite the simplicity of the technique, the second blood injection into the cisterna magna may result in brainstem injury leading to high mortality. Therefore, a modified double hemorrhage model of cisterna magna has been developed in rat recently. We describe here step by step the surgical technique to induce double SAH and compare the degree of vasospasm with other cisterna magna rat models using histological assessment of the diameter and cross-sectional area of the basilar artery.</description><identifier>ISSN: 2040-7378</identifier><identifier>EISSN: 2040-7378</identifier><identifier>EISSN: 1939-067X</identifier><identifier>DOI: 10.1186/2040-7378-4-23</identifier><identifier>PMID: 23194464</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Blood pressure ; Cerebral ischemia ; Experiments ; Gases ; Health aspects ; Intubation ; Morbidity ; Mortality ; Neurosurgery ; Rodents ; Stroke (Disease) ; Subarachnoid hemorrhage ; Veins & arteries</subject><ispartof>Experimental & translational stroke medicine, 2012-11, Vol.4 (1), p.23-23, Article 23</ispartof><rights>COPYRIGHT 2012 BioMed Central Ltd.</rights><rights>2012 Raslan et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright ©2012 Raslan et al.; licensee BioMed Central Ltd. 2012 Raslan et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4893-cace710550c6584623d21e003fcbc42bb8b8b17ef91900377fd2bddb3ed62fff3</citedby><cites>FETCH-LOGICAL-b4893-cace710550c6584623d21e003fcbc42bb8b8b17ef91900377fd2bddb3ed62fff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552945/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552945/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23194464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raslan, Furat</creatorcontrib><creatorcontrib>Albert-Weißenberger, Christiane</creatorcontrib><creatorcontrib>Westermaier, Thomas</creatorcontrib><creatorcontrib>Saker, Saker</creatorcontrib><creatorcontrib>Kleinschnitz, Christoph</creatorcontrib><creatorcontrib>Lee, Jin-Yul</creatorcontrib><title>A modified double injection model of cisterna magna for the study of delayed cerebral vasospasm following subarachnoid hemorrhage in rats</title><title>Experimental & translational stroke medicine</title><addtitle>Exp Transl Stroke Med</addtitle><description>Delayed cerebral vasospasm following subarachnoid hemorrhage (SAH) is a serious medical complication, characterized by constriction of cerebral arteries leading to varying degrees of cerebral ischemia. 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We describe here step by step the surgical technique to induce double SAH and compare the degree of vasospasm with other cisterna magna rat models using histological assessment of the diameter and cross-sectional area of the basilar artery.</description><subject>Blood pressure</subject><subject>Cerebral ischemia</subject><subject>Experiments</subject><subject>Gases</subject><subject>Health aspects</subject><subject>Intubation</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Neurosurgery</subject><subject>Rodents</subject><subject>Stroke (Disease)</subject><subject>Subarachnoid hemorrhage</subject><subject>Veins & arteries</subject><issn>2040-7378</issn><issn>2040-7378</issn><issn>1939-067X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kkuLFDEQxxtR3HX16lECgnjpNa9-XYRh8QULXvQc8qh0Z0h3xqR7l_kIfmvT7DrO6EogCVW_-ldRVUXxkuBLQtr6HcUclw1r2pKXlD0qzg-Gx0f_s-JZSluM647V-GlxRhnpOK_5efFzg8ZgnHVgkAmL8oDctAU9uzCtHvAoWKRdmiFOEo2yz7cNEc0DoDQvZr_6Myb3WUFDBBWlRzcyhbSTacys9-HWTT1Ki5JR6mEKzqABxhDjIPs1H4pyTs-LJ1b6BC_u34vi-8cP364-l9dfP3252lyXircdK7XU0BBcVVjXVctrygwlgDGzWmlOlWrzIQ3YjnTZ2jTWUGWMYmBqaq1lF8X7O93dokYwGqY5Vyx20Y0y7kWQTpx6JjeIPtwIVlW041UW2NwJKBf-I3Dq0WEU6yjEOgrBBWVZ4-19ETH8WCDNYnRJg_dygrAkQWibI2pa1Rl9_Re6DUuehV-phhLadZj8oXrpQbjJhpxar6JiUzHOm4YQmqnLB6h8DIxOhwmsy_aTgDdHAQNIPw8p-GVdj_Sgso4hpQj20A-Cxbqp_3bg1fEYDvjv1WS_AC6v5Q0</recordid><startdate>20121129</startdate><enddate>20121129</enddate><creator>Raslan, Furat</creator><creator>Albert-Weißenberger, Christiane</creator><creator>Westermaier, Thomas</creator><creator>Saker, Saker</creator><creator>Kleinschnitz, Christoph</creator><creator>Lee, Jin-Yul</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121129</creationdate><title>A modified double injection model of cisterna magna for the study of delayed cerebral vasospasm following subarachnoid hemorrhage in rats</title><author>Raslan, Furat ; Albert-Weißenberger, Christiane ; Westermaier, Thomas ; Saker, Saker ; Kleinschnitz, Christoph ; Lee, Jin-Yul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4893-cace710550c6584623d21e003fcbc42bb8b8b17ef91900377fd2bddb3ed62fff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Blood pressure</topic><topic>Cerebral ischemia</topic><topic>Experiments</topic><topic>Gases</topic><topic>Health aspects</topic><topic>Intubation</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Neurosurgery</topic><topic>Rodents</topic><topic>Stroke (Disease)</topic><topic>Subarachnoid hemorrhage</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raslan, Furat</creatorcontrib><creatorcontrib>Albert-Weißenberger, Christiane</creatorcontrib><creatorcontrib>Westermaier, Thomas</creatorcontrib><creatorcontrib>Saker, Saker</creatorcontrib><creatorcontrib>Kleinschnitz, Christoph</creatorcontrib><creatorcontrib>Lee, Jin-Yul</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental & translational stroke medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raslan, Furat</au><au>Albert-Weißenberger, Christiane</au><au>Westermaier, Thomas</au><au>Saker, Saker</au><au>Kleinschnitz, Christoph</au><au>Lee, Jin-Yul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A modified double injection model of cisterna magna for the study of delayed cerebral vasospasm following subarachnoid hemorrhage in rats</atitle><jtitle>Experimental & translational stroke medicine</jtitle><addtitle>Exp Transl Stroke Med</addtitle><date>2012-11-29</date><risdate>2012</risdate><volume>4</volume><issue>1</issue><spage>23</spage><epage>23</epage><pages>23-23</pages><artnum>23</artnum><issn>2040-7378</issn><eissn>2040-7378</eissn><eissn>1939-067X</eissn><abstract>Delayed cerebral vasospasm following subarachnoid hemorrhage (SAH) is a serious medical complication, characterized by constriction of cerebral arteries leading to varying degrees of cerebral ischemia. Numerous clinical and experimental studies have been performed in the last decades; however, the pathophysiologic mechanism of cerebral vasospasm after SAH still remains unclear. Among a variety of experimental SAH models, the double hemorrhage rat model involving direct injection of autologous arterial blood into the cisterna magna has been used most frequently for the study of delayed cerebral vasospasm following SAH in last years. Despite the simplicity of the technique, the second blood injection into the cisterna magna may result in brainstem injury leading to high mortality. Therefore, a modified double hemorrhage model of cisterna magna has been developed in rat recently. 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| subjects | Blood pressure Cerebral ischemia Experiments Gases Health aspects Intubation Morbidity Mortality Neurosurgery Rodents Stroke (Disease) Subarachnoid hemorrhage Veins & arteries |
| title | A modified double injection model of cisterna magna for the study of delayed cerebral vasospasm following subarachnoid hemorrhage in rats |
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