Segmental Motions, Not a Two-State Concerted Switch, Underlie Allostery in CheY

The switch between an inactive and active conformation is an important transition for signaling proteins, yet the mechanisms underlying such switches are not clearly understood. Escherichia coli CheY, a response regulator protein from the two-component signal transduction system that regulates bacte...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Structure (London) 2012-08, Vol.20 (8), p.1363-1373
Hauptverfasser:	McDonald, Leanna R., Boyer, Joshua A., Lee, Andrew L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Allosteric Regulation Allosteric Site Amino Acid Substitution Bacteria Bacterial Proteins - chemistry Bacterial Proteins - genetics Catalytic Domain Dispersions Dynamics Escherichia coli Escherichia coli Proteins Hydrogen Bonding Magnesium - chemistry Membrane Proteins - chemistry Membrane Proteins - genetics Methyl-Accepting Chemotaxis Proteins Models, Molecular Nuclear Magnetic Resonance, Biomolecular Protein Binding Protein Structure, Secondary Proteins Regulators Switches Switching
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!