Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β‑Lactams

Rising drug resistance is limiting treatment options for infections by methicillin-resistant Staphylococcus aureus (MRSA). Herein we provide new evidence that wall teichoic acid (WTA) biogenesis is a remarkable antibacterial target with the capacity to destabilize the cooperative action of penicilli...

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Veröffentlicht in:	ACS chemical biology 2013-01, Vol.8 (1), p.226-233
Hauptverfasser:	Farha, Maya A, Leung, Alexander, Sewell, Edward W, D’Elia, Michael A, Allison, Sarah E, Ejim, Linda, Pereira, Pedro M, Pinho, Mariana G, Wright, Gerard D, Brown, Eric D
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Lactams - chemistry beta-Lactams - metabolism beta-Lactams - pharmacology Cell Wall Methicillin-Resistant Staphylococcus aureus - drug effects Penicillin-Binding Proteins - chemistry Penicillin-Binding Proteins - metabolism Penicillin-Binding Proteins - pharmacology Teichoic Acids - antagonists & inhibitors Teichoic Acids - biosynthesis
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