Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion

An expanded GGGGCC hexanucleotide repeat in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal lobar degeneration associated with TDP-43 pathology (FTLD-TDP). In addition to TDP-43-positive neuronal and glial inclusions, C9ORF72 -linked FTLD-TDP has characte...

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Veröffentlicht in:	Acta neuropathologica 2013-02, Vol.125 (2), p.289-302
Hauptverfasser:	Bieniek, Kevin F., Murray, Melissa E., Rutherford, Nicola J., Castanedes-Casey, Monica, DeJesus-Hernandez, Mariely, Liesinger, Amanda M., Baker, Matthew C., Boylan, Kevin B., Rademakers, Rosa, Dickson, Dennis W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-protein Amyotrophic lateral sclerosis Analysis Atrophy Axons Binding proteins Cerebellum Cortex (temporal) Data Interpretation, Statistical DNA Repeat Expansion - genetics Female Fluorescent Antibody Technique Frontotemporal dementia Frontotemporal Lobar Degeneration - genetics Frontotemporal Lobar Degeneration - pathology Heterozygote Hippocampus Humans Image processing Image Processing, Computer-Assisted Immunohistochemistry Inclusion bodies Intercellular Signaling Peptides and Proteins - genetics Male Medicine Medicine & Public Health Microscopy, Fluorescence Middle Aged Mutation Mutation - genetics Neurodegenerative diseases Neurofibrillary tangles Neurofibrillary Tangles - pathology Neuronal-glial interactions Neurosciences Original Paper Pathology Protein binding Proteolysis Sex Factors Tau protein tau Proteins - genetics tau Proteins - physiology Ubiquitin
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