The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation

In animals, heterotrimeric guanine nucleotide-binding protein (G protein) signaling is initiated by G protein-coupled receptors (GPCRs), which activate G protein α subunits; however, the plant Arabidopsis thaliana lacks canonical GPCRs, and its G protein α subunit (AtGPA1) is self-activating. To inv...

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Veröffentlicht in:	Science signaling 2011-02, Vol.4 (159), p.ra8-ra8
Hauptverfasser:	Jones, Janice C, Duffy, Jeffrey W, Machius, Mischa, Temple, Brenda R S, Dohlman, Henrik G, Jones, Alan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - chemistry Adenosine Diphosphate - metabolism Adenosine Triphosphate - chemistry Adenosine Triphosphate - metabolism Amino Acid Sequence Arabidopsis Proteins - chemistry Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Circular Dichroism Crystallization GTP-Binding Protein alpha Subunits - chemistry GTP-Binding Protein alpha Subunits - genetics GTP-Binding Protein alpha Subunits - metabolism Guanine Nucleotide Exchange Factors - chemistry Guanine Nucleotide Exchange Factors - metabolism Kinetics Models, Molecular Molecular Sequence Data Mutation Protein Binding Protein Folding Protein Structure, Secondary Protein Structure, Tertiary Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - metabolism Sequence Homology, Amino Acid Signal Transduction X-Ray Diffraction
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