p27Kip1 Directly Represses Sox2 during Embryonic Stem Cell Differentiation

The mechanisms responsible for the transcriptional silencing of pluripotency genes in differentiated cells are poorly understood. We have observed that cells lacking the tumor suppressor p27 can be reprogrammed into induced pluripotent stem cells (iPSCs) in the absence of ectopic Sox2. Interestingly...

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Veröffentlicht in:	Cell stem cell 2012-12, Vol.11 (6), p.845-852
Hauptverfasser:	Li, Han, Collado, Manuel, Villasante, Aranzazu, Matheu, Ander, Lynch, Cian J., Cañamero, Marta, Rizzoti, Karine, Carneiro, Carmen, Martínez, Gloria, Vidal, Anxo, Lovell-Badge, Robin, Serrano, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Molecular and cellular biology Short
Online-Zugang:	Volltext
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