Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction

Nicotinamide phosphoribosyltransferase (Nampt) is a key enzyme for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and recent evidence indicates its role in inflammatory processes. Here, we investigated the potential effects of pharmacological Nampt inhibition with FK866 in a mouse myocardi...

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Veröffentlicht in:	Antioxidants & redox signaling 2013-02, Vol.18 (6), p.630-641
Hauptverfasser:	Montecucco, Fabrizio, Bauer, Inga, Braunersreuther, Vincent, Bruzzone, Santina, Akhmedov, Alexander, Lüscher, Thomas F, Speer, Timo, Poggi, Alessandro, Mannino, Elena, Pelli, Graziano, Galan, Katia, Bertolotto, Maria, Lenglet, Sébastien, Garuti, Anna, Montessuit, Christophe, Lerch, René, Pellieux, Corinne, Vuilleumier, Nicolas, Dallegri, Franco, Mage, Jacqueline, Sebastian, Carlos, Mostoslavsky, Raul, Gayet-Ageron, Angèle, Patrone, Franco, Mach, François, Nencioni, Alessio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - administration & dosage Animals Chemokine CXCL2 - metabolism Forum Original Research Communication Humans Male Mice Myocardial Infarction - drug therapy Myocardial Infarction - enzymology Myocardial Infarction - pathology Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - pathology NAD - biosynthesis Neutrophil Infiltration - drug effects Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors Nicotinamide Phosphoribosyltransferase - metabolism Oxidative Stress - drug effects Piperidines - administration & dosage Reactive Oxygen Species - metabolism Signal Transduction
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