Structure and Function of Human Xylulokinase, an Enzyme with Important Roles in Carbohydrate Metabolism

d-Xylulokinase (XK; EC 2.7.1.17) catalyzes the ATP-dependent phosphorylation of d-xylulose (Xu) to produce xylulose 5-phosphate (Xu5P). In mammals, XK is the last enzyme in the glucuronate-xylulose pathway, active in the liver and kidneys, and is linked through its product Xu5P to the pentose-phosph...

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Veröffentlicht in:	The Journal of biological chemistry 2013-01, Vol.288 (3), p.1643-1652
Hauptverfasser:	Bunker, Richard D., Bulloch, Esther M.M., Dickson, James M.J., Loomes, Kerry M., Baker, Edward N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - chemistry Adenosine Diphosphate - metabolism Carbohydrate Metabolism Catalytic Domain Crystallography, X-Ray Enzyme Catalysis Enzyme Inhibitors Escherichia coli - genetics Gene Expression Humans Hydrogen Bonding Kinetics Lipogenesis Magnetic Resonance Spectroscopy Models, Molecular Pentosephosphates - chemistry Pentosephosphates - metabolism Phosphotransferases (Alcohol Group Acceptor) - chemistry Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Protein Structure Protein Structure and Folding Protein Structure, Secondary Protein Structure, Tertiary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Substrate Specificity X-ray Crystallography Xylulose - analogs & derivatives Xylulose - metabolism Xylulose Kinase
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