Triflumizole Is an Obesogen in Mice that Acts through Peroxisome Proliferator Activated Receptor Gamma (PPARγ)

Background: Triflumizole (TFZ) is an imidazole fungicide used on many food and ornamental crops. TFZ is not thought to be particularly toxic or carcinogenic, but little is known about its effect on development. TFZ is identified as a peroxisome proliferator activated receptor gamma (PPARγ) activator...

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Veröffentlicht in:	Environmental health perspectives 2012-12, Vol.120 (12), p.1720-1726
Hauptverfasser:	Li, Xia, Pham, Hang T., Janesick, Amanda S., Blumberg, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 L1 cells Adipocytes Animals Biocompatibility Biological and medical sciences Biomedical materials Body weight Dimethyl Sulfoxide - pharmacology Dosage Drug therapy Environment. Living conditions Environmental agencies Environmental Pollutants - toxicity Female Fungicides Gene expression Gene Expression - drug effects Gene Expression Regulation - drug effects Health aspects Imidazoles - toxicity In vivo testing In vivo tests Lipogenesis Male Medical sciences Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mice Nanostructure Obesity Peroxisomes PPAR gamma - agonists PPAR gamma - antagonists & inhibitors Public health. Hygiene Public health. Hygiene-occupational medicine Receptors Surgical implants Thiazolidinediones - pharmacology Toxicology Triglycerides - metabolism
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