Immunoglobulin class-switch DNA recombination: induction, targeting and beyond

Key Points T cell-dependent and T cell-independent primary class-switch DNA recombination (CSR)-inducing stimuli induce activation-induced cytidine deaminase (AID) in a B cell differentiation stage-specific manner. AID expression is further enhanced by secondary CSR-inducing stimuli — namely, interl...

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Veröffentlicht in:	Nature reviews. Immunology 2012-07, Vol.12 (7), p.517-531
Hauptverfasser:	Xu, Zhenming, Zan, Hong, Pone, Egest J., Mai, Thach, Casali, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 protein 14-3-3 Proteins - metabolism 40 631/250/2152/2498 631/250/2502/2170 Activation-induced cytidine deaminase Animals Antibodies Antibody response Antigens Biomedical and Life Sciences Biomedicine Chromatin Class switching Cytidine deaminase Cytidine Deaminase - metabolism Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded Epigenesis, Genetic epigenetics Genetic recombination Heavy chains Histones Humans Immunoglobulin Class Switching - genetics Immunoglobulin Class Switching - physiology Immunoglobulins Immunology Kinases Macromolecules Mice Models, Genetic Models, Immunological Pathogens Physiological aspects Recombination Recombination, Genetic review-article Transcription Transcription activation
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