P-body components LSM1, GW182, DDX3, DDX6 and XRN1 are recruited to WNV replication sites and positively regulate viral replication

Abstract In mammalian cells, proteins involved in mRNA silencing and degradation localize to discrete cytoplasmic foci called processing or P-bodies. Here we show that microscopically visible P-bodies are greatly diminished following West Nile viral infection, but the component proteins are not depl...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2013-02, Vol.436 (1), p.1-7
Hauptverfasser:	Chahar, Harendra S, Chen, Shuiping, Manjunath, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantigens - genetics Autoantigens - metabolism Cell Line, Tumor Cricetinae DDX3 DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Exoribonucleases - genetics Exoribonucleases - metabolism Flavivirus Geographic Information Systems GW182 HeLa Cells Humans Infectious Disease LSM1 Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism P-body Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RNA Helicases - metabolism RNA Interference RNA, Small Interfering RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism RNAi Serine Endopeptidases - metabolism Viral Nonstructural Proteins - metabolism Virus Replication - physiology West Nile Fever - metabolism West Nile virus West Nile virus - growth & development West Nile virus - metabolism
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