Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis

G protein signaling pathways, as key components of physiologic responsiveness and timing, are frequent targets for pharmacologic intervention. Here, we identify an effector for heterotrimeric G protein α subunit (EhGα1) signaling from Entamoeba histolytica, the causative agent of amoebic colitis. Eh...

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Veröffentlicht in:	Structure 2013-01, Vol.21 (1), p.65-75
Hauptverfasser:	Bosch, Dustin E., Kimple, Adam J., Manning, Alyssa J., Muller, Robin E., Willard, Francis S., Machius, Mischa, Rogers, Stephen L., Siderovski, David P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Binding Sites Cell Adhesion Cell Line Cell Shape Cell Survival Chemotaxis Crystallography, X-Ray Drosophila Drosophila melanogaster Entamoeba histolytica Entamoeba histolytica - metabolism Entamoeba histolytica - physiology GTP-Binding Protein alpha Subunits - chemistry Guanine Nucleotide Exchange Factors - chemistry Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Guanosine Triphosphate - chemistry Host-Parasite Interactions Hydrolysis Models, Molecular Mutagenesis, Site-Directed Protein Binding Protein Interaction Domains and Motifs Protein Structure, Secondary Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - metabolism Rho Guanine Nucleotide Exchange Factors Signal Transduction Trophozoites - metabolism Trophozoites - physiology
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