Y-Family Polymerase Conformation Is a Major Determinant of Fidelity and Translesion Specificity

Y-family polymerases help cells tolerate DNA damage by performing translesion synthesis opposite damaged DNA bases, yet they also have a high intrinsic error rate. We constructed chimeras of two closely related Y-family polymerases that display distinctly different activity profiles and found that t...

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Veröffentlicht in:	Structure (London) 2013-01, Vol.21 (1), p.20-31
Hauptverfasser:	Wilson, Ryan C., Jackson, Meghan A., Pata, Janice D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Apurinic Acid - genetics Archaeal Proteins - chemistry Archaeal Proteins - genetics Base Sequence Catalysis Catalysts Catalytic Domain Crystallography, X-Ray Damage tolerance Deoxyribonucleic acid Determinants DNA Polymerase beta - chemistry DNA Polymerase beta - genetics DNA Repair Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Polymerase Polypeptides Protein Binding Protein Structure, Secondary Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Residues Substrate Specificity Sulfolobus acidocaldarius - enzymology Sulfolobus solfataricus - enzymology
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