Insulin suppression of apolipoprotein B in McArdle RH7777 cells involves increased sortilin 1 interaction and lysosomal targeting

► Insulin suppresses VLDL B100 secretion via PI3K in McArdle RH7777 rat hepatoma cells. ► Insulin enhances sortilin 1–B100 interaction. ► Inhibition of lysosomal degradation by BafA1 blocks insulin suppression of VLDL B100. ► BafA1 inhibition reveals increased insulin-dependent sortilin 1–B100 inter...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2013-01, Vol.430 (1), p.66-71
Hauptverfasser:	Chamberlain, Jeffrey M., O’Dell, Colleen, Sparks, Charles E., Sparks, Janet D.
Format:	Artikel
Sprache:	eng
Schlagworte:	acidification Adaptor Proteins, Vesicular Transport - metabolism Animals Apo B degradation apolipoprotein B Apolipoproteins B - antagonists & inhibitors Apolipoproteins B - metabolism Bafilomycin A1 Cell Line crosslinking hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Insulin Insulin - pharmacology Lipoprotein secretion Lipoproteins, VLDL - antagonists & inhibitors Lipoproteins, VLDL - metabolism liver lysosomes Lysosomes - drug effects Lysosomes - metabolism Macrolides - pharmacology Phosphatidylinositide 3-kinase phosphatidylinositol 3-kinase proteolysis Rats reticulum rodents secretion Sortilin 1 very low density lipoprotein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!