Dry Needling at Myofascial Trigger Spots of Rabbit Skeletal Muscles Modulates the Biochemicals Associated with Pain, Inflammation, and Hypoxia
Background and Purpose. Dry needling is an effective therapy for the treatment of pain associated with myofascial trigger point (MTrP). However, the biochemical effects of dry needling that are associated with pain, inflammation, and hypoxia are unclear. This study investigated the activities of β-e...
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| description | Background and Purpose. Dry needling is an effective therapy for the treatment of pain associated with myofascial trigger point (MTrP). However, the biochemical effects of dry needling that are associated with pain, inflammation, and hypoxia are unclear. This study investigated the activities of β-endorphin, substance P, TNF-α, COX-2, HIF-1α, iNOS, and VEGF after different dosages of dry needling at the myofascial trigger spots (MTrSs) of a skeletal muscle in rabbit. Materials and Methods. Dry needling was performed either with one dosage (1D) or five dosages (5D) into the biceps femoris with MTrSs in New Zealand rabbits. Biceps femoris, serum, and dorsal root ganglion (DRG) were sampled immediately and 5 d after dry needling for β-endorphin, substance P, TNF-α, COX-2, HIF-1α, iNOS, and VEGF immunoassays. Results. The 1D treatment enhanced the β-endorphin levels in the biceps femoris and serum and reduced substance P in the biceps femoris and DRG. The 5D treatment reversed these effects and was accompanied by increase of TNF-α, COX-2, HIF-1α, iNOS, and VEGF production in the biceps femoris. Moreover, the higher levels of these biochemicals were still maintained 5 d after treatment. Conclusion. Dry needling at the MTrSs modulates various biochemicals associated with pain, inflammation, and hypoxia in a dose-dependent manner. |
| doi_str_mv | 10.1155/2012/342165 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3544533</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1282043605</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-fc03888405703896001e111ee4a2dc04e7a6d24f4d738eb31ea7156f0ec135993</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhSNERUthxRpkiQ0Chvovfxuk0gKt1AFEi8TOuuPcTNw68WA7tPMSfWY8ShkBG1Y-lj9_ulcny54w-oaxPD_glPEDITkr8nvZHislm0leVfe3ufy-mz0M4ZJSXpdl-SDb5ULIgtXVXnZ77NfkE2JjzbAkEMl87VoI2oAlF94sl-jJ-crFQFxLvsJiYSI5v0KLMQHzMWiLgcxdM1qIKcUOyTvjdIe90WADOQzBJVnEhlyb2JEvYIbX5HRoLfQ9ROPSDYaGnKxX7sbAo2ynTd_w8d25n3378P7i6GR29vnj6dHh2UzLooizVlNRVZWkeZlCXVDKkDGGKIE3mkosoWi4bGVTigoXgiGULC9aipqJvK7FfvZ28q7GRY-NxiF6sGrlTQ9-rRwY9ffLYDq1dD-VyKXMhUiCF3cC736MGKLqTdBoLQzoxqAYrziVoqB5Qp__g1660Q9pPcVpQSvGZM0T9WqitHcheGy3wzCqNj2rTc9q6jnRz_6cf8v-LjYBLyegM0MD1-Y_tqcTjAnBFrZwXfPNFr8AH426EQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2060811492</pqid></control><display><type>article</type><title>Dry Needling at Myofascial Trigger Spots of Rabbit Skeletal Muscles Modulates the Biochemicals Associated with Pain, Inflammation, and Hypoxia</title><source>Wiley Online Library Open Access</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Chou, Li-Wei ; Yang, Chen-Chia ; Yang, Shun-An ; Hsieh, Yueh-Ling</creator><contributor>Hong, Chang-Zern</contributor><creatorcontrib>Chou, Li-Wei ; Yang, Chen-Chia ; Yang, Shun-An ; Hsieh, Yueh-Ling ; Hong, Chang-Zern</creatorcontrib><description>Background and Purpose. Dry needling is an effective therapy for the treatment of pain associated with myofascial trigger point (MTrP). However, the biochemical effects of dry needling that are associated with pain, inflammation, and hypoxia are unclear. This study investigated the activities of β-endorphin, substance P, TNF-α, COX-2, HIF-1α, iNOS, and VEGF after different dosages of dry needling at the myofascial trigger spots (MTrSs) of a skeletal muscle in rabbit. Materials and Methods. Dry needling was performed either with one dosage (1D) or five dosages (5D) into the biceps femoris with MTrSs in New Zealand rabbits. Biceps femoris, serum, and dorsal root ganglion (DRG) were sampled immediately and 5 d after dry needling for β-endorphin, substance P, TNF-α, COX-2, HIF-1α, iNOS, and VEGF immunoassays. Results. The 1D treatment enhanced the β-endorphin levels in the biceps femoris and serum and reduced substance P in the biceps femoris and DRG. The 5D treatment reversed these effects and was accompanied by increase of TNF-α, COX-2, HIF-1α, iNOS, and VEGF production in the biceps femoris. Moreover, the higher levels of these biochemicals were still maintained 5 d after treatment. Conclusion. Dry needling at the MTrSs modulates various biochemicals associated with pain, inflammation, and hypoxia in a dose-dependent manner.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2012/342165</identifier><identifier>PMID: 23346198</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Biochemistry ; Cyclooxygenase-2 ; Dorsal root ganglia ; Endorphins ; Hypoxia ; Hypoxia-inducible factor 1 ; Immunoassay ; Immunoassays ; Muscles ; Musculoskeletal system ; Nitric oxide ; Nitric-oxide synthase ; Pain ; Rabbits ; Skeletal muscle ; Substance P ; Tumor necrosis factor ; Tumor necrosis factor-TNF ; Vascular endothelial growth factor</subject><ispartof>Evidence-based complementary and alternative medicine, 2012-01, Vol.2012 (2012), p.1-12</ispartof><rights>Copyright © 2012 Yueh-Ling Hsieh et al.</rights><rights>Copyright © 2012 Yueh-Ling Hsieh et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2012 Yueh-Ling Hsieh et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-fc03888405703896001e111ee4a2dc04e7a6d24f4d738eb31ea7156f0ec135993</citedby><cites>FETCH-LOGICAL-c466t-fc03888405703896001e111ee4a2dc04e7a6d24f4d738eb31ea7156f0ec135993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544533/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544533/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23346198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hong, Chang-Zern</contributor><creatorcontrib>Chou, Li-Wei</creatorcontrib><creatorcontrib>Yang, Chen-Chia</creatorcontrib><creatorcontrib>Yang, Shun-An</creatorcontrib><creatorcontrib>Hsieh, Yueh-Ling</creatorcontrib><title>Dry Needling at Myofascial Trigger Spots of Rabbit Skeletal Muscles Modulates the Biochemicals Associated with Pain, Inflammation, and Hypoxia</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Background and Purpose. Dry needling is an effective therapy for the treatment of pain associated with myofascial trigger point (MTrP). However, the biochemical effects of dry needling that are associated with pain, inflammation, and hypoxia are unclear. This study investigated the activities of β-endorphin, substance P, TNF-α, COX-2, HIF-1α, iNOS, and VEGF after different dosages of dry needling at the myofascial trigger spots (MTrSs) of a skeletal muscle in rabbit. Materials and Methods. Dry needling was performed either with one dosage (1D) or five dosages (5D) into the biceps femoris with MTrSs in New Zealand rabbits. Biceps femoris, serum, and dorsal root ganglion (DRG) were sampled immediately and 5 d after dry needling for β-endorphin, substance P, TNF-α, COX-2, HIF-1α, iNOS, and VEGF immunoassays. Results. The 1D treatment enhanced the β-endorphin levels in the biceps femoris and serum and reduced substance P in the biceps femoris and DRG. The 5D treatment reversed these effects and was accompanied by increase of TNF-α, COX-2, HIF-1α, iNOS, and VEGF production in the biceps femoris. Moreover, the higher levels of these biochemicals were still maintained 5 d after treatment. Conclusion. Dry needling at the MTrSs modulates various biochemicals associated with pain, inflammation, and hypoxia in a dose-dependent manner.</description><subject>Biochemistry</subject><subject>Cyclooxygenase-2</subject><subject>Dorsal root ganglia</subject><subject>Endorphins</subject><subject>Hypoxia</subject><subject>Hypoxia-inducible factor 1</subject><subject>Immunoassay</subject><subject>Immunoassays</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Pain</subject><subject>Rabbits</subject><subject>Skeletal muscle</subject><subject>Substance P</subject><subject>Tumor necrosis factor</subject><subject>Tumor necrosis factor-TNF</subject><subject>Vascular endothelial growth factor</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc1u1DAUhSNERUthxRpkiQ0Chvovfxuk0gKt1AFEi8TOuuPcTNw68WA7tPMSfWY8ShkBG1Y-lj9_ulcny54w-oaxPD_glPEDITkr8nvZHislm0leVfe3ufy-mz0M4ZJSXpdl-SDb5ULIgtXVXnZ77NfkE2JjzbAkEMl87VoI2oAlF94sl-jJ-crFQFxLvsJiYSI5v0KLMQHzMWiLgcxdM1qIKcUOyTvjdIe90WADOQzBJVnEhlyb2JEvYIbX5HRoLfQ9ROPSDYaGnKxX7sbAo2ynTd_w8d25n3378P7i6GR29vnj6dHh2UzLooizVlNRVZWkeZlCXVDKkDGGKIE3mkosoWi4bGVTigoXgiGULC9aipqJvK7FfvZ28q7GRY-NxiF6sGrlTQ9-rRwY9ffLYDq1dD-VyKXMhUiCF3cC736MGKLqTdBoLQzoxqAYrziVoqB5Qp__g1660Q9pPcVpQSvGZM0T9WqitHcheGy3wzCqNj2rTc9q6jnRz_6cf8v-LjYBLyegM0MD1-Y_tqcTjAnBFrZwXfPNFr8AH426EQ</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Chou, Li-Wei</creator><creator>Yang, Chen-Chia</creator><creator>Yang, Shun-An</creator><creator>Hsieh, Yueh-Ling</creator><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Dry Needling at Myofascial Trigger Spots of Rabbit Skeletal Muscles Modulates the Biochemicals Associated with Pain, Inflammation, and Hypoxia</title><author>Chou, Li-Wei ; Yang, Chen-Chia ; Yang, Shun-An ; Hsieh, Yueh-Ling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-fc03888405703896001e111ee4a2dc04e7a6d24f4d738eb31ea7156f0ec135993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biochemistry</topic><topic>Cyclooxygenase-2</topic><topic>Dorsal root ganglia</topic><topic>Endorphins</topic><topic>Hypoxia</topic><topic>Hypoxia-inducible factor 1</topic><topic>Immunoassay</topic><topic>Immunoassays</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>Pain</topic><topic>Rabbits</topic><topic>Skeletal muscle</topic><topic>Substance P</topic><topic>Tumor necrosis factor</topic><topic>Tumor necrosis factor-TNF</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chou, Li-Wei</creatorcontrib><creatorcontrib>Yang, Chen-Chia</creatorcontrib><creatorcontrib>Yang, Shun-An</creatorcontrib><creatorcontrib>Hsieh, Yueh-Ling</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chou, Li-Wei</au><au>Yang, Chen-Chia</au><au>Yang, Shun-An</au><au>Hsieh, Yueh-Ling</au><au>Hong, Chang-Zern</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dry Needling at Myofascial Trigger Spots of Rabbit Skeletal Muscles Modulates the Biochemicals Associated with Pain, Inflammation, and Hypoxia</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>2012</volume><issue>2012</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Background and Purpose. Dry needling is an effective therapy for the treatment of pain associated with myofascial trigger point (MTrP). However, the biochemical effects of dry needling that are associated with pain, inflammation, and hypoxia are unclear. This study investigated the activities of β-endorphin, substance P, TNF-α, COX-2, HIF-1α, iNOS, and VEGF after different dosages of dry needling at the myofascial trigger spots (MTrSs) of a skeletal muscle in rabbit. Materials and Methods. Dry needling was performed either with one dosage (1D) or five dosages (5D) into the biceps femoris with MTrSs in New Zealand rabbits. Biceps femoris, serum, and dorsal root ganglion (DRG) were sampled immediately and 5 d after dry needling for β-endorphin, substance P, TNF-α, COX-2, HIF-1α, iNOS, and VEGF immunoassays. Results. The 1D treatment enhanced the β-endorphin levels in the biceps femoris and serum and reduced substance P in the biceps femoris and DRG. The 5D treatment reversed these effects and was accompanied by increase of TNF-α, COX-2, HIF-1α, iNOS, and VEGF production in the biceps femoris. Moreover, the higher levels of these biochemicals were still maintained 5 d after treatment. Conclusion. Dry needling at the MTrSs modulates various biochemicals associated with pain, inflammation, and hypoxia in a dose-dependent manner.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>23346198</pmid><doi>10.1155/2012/342165</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biochemistry Cyclooxygenase-2 Dorsal root ganglia Endorphins Hypoxia Hypoxia-inducible factor 1 Immunoassay Immunoassays Muscles Musculoskeletal system Nitric oxide Nitric-oxide synthase Pain Rabbits Skeletal muscle Substance P Tumor necrosis factor Tumor necrosis factor-TNF Vascular endothelial growth factor |
| title | Dry Needling at Myofascial Trigger Spots of Rabbit Skeletal Muscles Modulates the Biochemicals Associated with Pain, Inflammation, and Hypoxia |
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