Coordinate regulation between expression levels of telomere‐binding proteins and telomere length in breast carcinomas

Telomere dysregulation occurs in both the in situ and invasive stages of many carcinomas, including breast. Knockout experiments have identified several telomere‐associated proteins required for proper telomere function and maintenance, including telomere repeat‐binding factor 1 and 2 (TRF1 and TRF2...

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Veröffentlicht in:	Cancer medicine (Malden, MA) MA), 2012-10, Vol.1 (2), p.165-175
Hauptverfasser:	Butler, Kimberly S., Hines, William C., Heaphy, Christopher M., Griffith, Jeffrey K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Breast cancer Breast carcinoma Breast Neoplasms - genetics Breast Neoplasms - metabolism Carcinoma - genetics Carcinoma - metabolism Cell Line, Tumor Chromosomes Clinical Cancer Research Deoxyribonucleic acid Dexamethasone Dexamethasone - metabolism DNA Female Glucocorticoids Humans Inflammation Invasiveness Lymphatic system MCF-7 Cells Medical research Middle Aged NF-kappa B - metabolism Polymerase chain reaction Promoter Regions, Genetic Proteins Regulation Reverse transcription RNA, Messenger - biosynthesis RNA-directed DNA polymerase Telomerase Telomerase - genetics Telomerase - metabolism Telomerase reverse transcriptase Telomere - genetics Telomere Homeostasis telomere maintenance Telomere-binding protein Telomere-Binding Proteins - biosynthesis Telomere-Binding Proteins - genetics Telomere-Binding Proteins - metabolism Telomeres telomere‐binding proteins Telomeric Repeat Binding Protein 1 - genetics Telomeric Repeat Binding Protein 1 - metabolism Telomeric Repeat Binding Protein 2 - genetics Telomeric Repeat Binding Protein 2 - metabolism Transcription factors TRF2 protein Tumor cell lines Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumors Yeast
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